Social cognition over time in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort

SCHIZOPHRENIA RESEARCH

卷:171

Article

Piskulic, Danijela¹  Liu, Lu¹  Cadenhead, Kristin S.²  Cannon, Tyrone D.³  Cornblatt, Barbara A.⁴  McGlashan, Thomas H.⁵  Perkins, Diana O.⁶  Seidman, Larry J.^7,8  Tsuang, Ming T.^2,9  Walker, Elaine F.¹⁰  Woods, Scott W.⁵  Bearden, Carrie E.^11,12  Mathalon, Daniel H.^13,14  Addington, Jean¹ 

[1] Univ Calgary, Dept Psychiat, Hotchkiss Brain Inst, Calgary, AB T2N 4Z6, Canada

[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[3] Yale Univ, Dept Psychol, New Haven, CT USA

[4] Zucker Hillside Hosp, Dept Psychiat, Queens, NY USA

[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[6] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[7] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Psychiat, Boston, MA 02215 USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA

[10] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[11] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[12] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[13] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[14] Psychiat Serv, San Francisco, CA USA

关键词: Social cognition;    Theory of mind;    Social perception;    Emotion perception;    Clinical high risk;    Psychosis;   

DOI  :  10.1016/j.schres.2016.01.017

来源: Elsevier

【 摘 要 】

Deficits in social cognition arewell established in schizophrenia and have been observed prior to the illness onset. Compared to healthy controls (HCs), individuals at clinical high risk of psychosis (CHR) are said to show deficits in social cognition similar to those observed in patients experiencing a first episode of psychosis. These deficits have been observed in several domains of social cognition, such as theory of mind (ToM), emotion perception and social perception. In the current study, the stability of three domains of social cognition (ToM, social perception and facial emotion perception) was assessed over time along and their association with both clinical symptoms and the later development of psychosis. Six hundred and seventy-five CHR individuals and 264 HC participants completed four tests of social cognition at baseline. Of those, 160 CHR and 155 HC participants completed assessments at all three time points (baseline, 1 year and 2 years) as part of their participation in the North American Prodrome Longitudinal Study. The CHR group performed poorer on all tests of social cognition across all time points compared to HCs. Social cognition was not associated with attenuated positive symptoms at any time point in the study. CHR individuals who developed a psychotic disorder during the course of the study did not differ in social cognition compared to those who did not develop psychosis. This longitudinal study demonstrated mild to moderate, but persistent ToM and social perception impairments in those at CHR for psychosis compared to HCs. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free