The search for an autoimmune origin of psychotic disorders: Prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens

SCHIZOPHRENIA RESEARCH

卷:228

Article

Hoffmann, Carolin^1,9  Zong, Shenghua¹  Mane-Damas, Marina¹  Stevens, Jo^1,10  Malyavantham, Kishore^2,11  Kucukali, Cem Ismail³  Tuzun, Erdem³  De Hert, Marc^4,5  van Beveren, Nico J. M.⁶  Gonzalez-Vioque, Emiliano^7,12  Arango, Celso⁷  Damoiseaux, Jan G. M. C.⁸  Rutten, Bart P.¹  Molenaar, Peter C.¹  Losen, Mario¹  Martinez-Martinez, Pilar¹ 

[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[2] IMMCO Diagnost Inc, 60 Pineview Dr, Buffalo, NY USA

[3] Istanbul Univ, Inst Expt Med Res DETAE, Dept Neurosci, Istanbul, Turkey

[4] Katholieke Univ Leuven, UPC KU Leuven, Dept Neurosci, Leuven, Belgium

[5] Univ Antwerp, Antwerp Hlth Law & Eth Chair AHLEC, Antwerp, Belgium

[6] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands

[7] Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med, Child & Adolescent Psychiat Dept,IiSGM,CIBERSAM, Madrid, Spain

[8] Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht, Netherlands

[9] Univ Algarve, Ctr Biomed Res CBMR, Faro, Portugal

[10] Roche Diagnost, Antibody Dev, Centralized & Point Care Solut, Penzberg, Germany

[11] Nova Diagnost, San Diego, CA USA

[12] Hosp Clin Univ Santiago de Compostela, Hlth Res Inst Santiago de Compostela IDIS, Unit Diag & Treatment Congenital Metab Dis, Santiago De Compostela, Spain

关键词: Psychoses;    Neuroimmunology;    Autoantibodies;   

DOI  :  10.1016/j.schres.2020.12.038

来源: Elsevier

【 摘 要 】

The etiology of psychotic disorders is still unknown, but in a subgroup of patients symptoms might be caused by an autoimmune reaction. In this study, we tested patterns of autoimmune reactivity against potentially novel hippocampal antigens. Serum of a cohort of 621 individuals with psychotic disorders and 257 controls were first tested for reactivity on neuropil of rat brain sections. Brain reactive sera (67 diseased, 27 healthy) were further tested for antibody binding to glutamic acid decarboxylase (GAD) isotype 65 and 67 by cell-based assay (CBA). A sub-cohort of 199 individuals with psychotic disorders and 152 controls was tested for the prevalence of anti-nuclear antibodies (ANA) on HEp2-substrate aswell as for reactivity to double-strandedDNA, ribosomal P (RPP), and cardiolipin (CL). Incubation of rat brain with serumresulted in unidentified hippocampal binding patterns in both diseased and control groups. Upon screening with GAD CBA, one of these patterns was identified as GAD65 in one individual with schizophrenia and also in one healthy individual. Two diseased and two healthy individuals had low antibody levels targeting GAD67 by CBA. Antibody reactivity on HEp-2-substrate was increased in patients with schizoaffective disorder, but only in 3 patients did antibody testing hint at a possible diagnosis of systemic lupus erythematosus. Although reactivity of serum to intracellular antigens might be increased in patients with psychotic disorder, no specific targets could be identified. GAD antibodies are very rare and do not seem increased in serum of patients with psychotic disorders. (C) 2021 The Authors. Published by Elsevier B.V.

【 授权许可】

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