Cannabis use is associated with 3 years earlier onset of schizophrenia spectrum disorder in a naturalistic, multi-site sample (N=1119)

SCHIZOPHRENIA RESEARCH

卷:170

Article

Helle, Siri¹  Ringen, Petter Andreas^2,3  Melle, Ingrid^2,3  Larsen, Tor-Ketil^4,5  Gjestad, Rolf¹  Johnsen, Erik¹  Lagerberg, Trine Vik^2,3  Andreassen, Ole A.^2,3  Kroken, Rune Andreas^1,5  Joa, Inge^4,6  Hegelstad, Wenche ten Velden⁴  Loberg, Else-Marie^1,7 

[1] Haukeland Hosp, Div Psychiat, N-5035 Bergen, Norway

[2] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

[3] Univ Oslo, NORMENT KG Jebsen Ctr Psychosis Res, Inst Clin Med, N-0316 Oslo, Norway

[4] Stavanger Univ Hosp, Div Psychiat, Ctr Clin Res Psychosis, Stavanger, Norway

[5] Univ Bergen, Dept Clin Med, N-5020 Bergen, Norway

[6] Univ Stavanger, Fac Social Sci, Network Med Sci, Stavanger, Norway

[7] Univ Bergen, Dept Clin Psychol, N-5020 Bergen, Norway

关键词: Schizophrenia;    Non-affective psychosis;    Age at onset;    Cannabis;    Substance;    Substance use;   

DOI  :  10.1016/j.schres.2015.11.027

来源: Elsevier

【 摘 要 】

Background: Patients with schizophrenia spectrum disorders and substance use may have an earlier onset of illness compared to those without substance use. Most previous studies have, however, too small samples to control for confounding variables and the effect of specific types of substances. The present study aimed to examine the relationship between substance use and age at onset, in addition to the influence of possible confounders and specific substances, in a large and heterogeneous multisite sample of patients with schizophrenia spectrum disorders. Methods: The patients (N=1119) were recruited from catchment areas in Oslo, Stavanger and Bergen, Norway, diagnosed according to DSM-IV and screened for substance use history. Linear regression analysis was used to examine the relationship between substance use and age at onset of illness. Results: Patients with substance use (n=627) had about 3 years earlier age at onset (23.0 years; SD 7.1) than the abstinent group (n=492; 25.9 years; SD 9.7). Only cannabis use was statistically significantly related to earlier age at onset. Gender or family history of psychosis did not influence the results. Conclusion: Cannabis use is associated with 3 years earlier onset of psychosis. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

【 授权许可】

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