Evaluating the relationship between cannabis use and IQ in youth and young adults at clinical high risk of psychosis

PSYCHIATRY RESEARCH

卷:230

Article

Buchy, Lisa¹  Seidman, Larry J.²  Cadenhead, Kristin S.³  Cannon, Tyrone D.⁴  Cornblatt, Barbara A.⁵  McGlashan, Thomas H.⁶  Perkins, Diana O.^7,8  Stone, William²  Tsuang, Ming T.³  Walker, Elaine F.^9,10  Woods, Scott W.⁵  Bearden, Carrie E.^11,12  Mathalon, Daniel H.¹³  Addington, Jean¹ 

[1] Univ Calgary, Dept Psychiat, Calgary, AB T2N 4Z6, Canada

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Psychiat, Boston, MA 02215 USA

[3] UCSD, Dept Psychiat, La Jolla, CA USA

[4] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[5] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA

[6] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[7] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[10] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA

[11] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA

[12] Univ Calif Los Angeles, Dept Biobehav Sci & Psychol, Los Angeles, CA USA

[13] Univ Calif San Francisco, San Francisco, CA 94143 USA

关键词: Age at onset;    Alcohol;    Cannabis;    IQ;    Prodrome;    Schizophrenia;   

DOI  :  10.1016/j.psychres.2015.11.033

来源: Elsevier

【 摘 要 】

Among people with psychosis, those with a history of cannabis use show better cognitive performance than those who are cannabis naive. It is unknown whether this pattern is present in youth at clinical high risk (CHR) of psychosis. We evaluated relationships between IQ and cannabis use while controlling for use of other substances known to impact cognition in 678 CHR and 263 healthy control (HC) participants. IQ was estimated using the Vocabulary and Block Design subtests of the Wechsler Abbreviated Scale of Intelligence. Drug and alcohol use severity and frequency were assessed with the Alcohol and Drug Use Scale, and we inquired participants' age at first use. CHR were further separated into early and late age at onset of cannabis use sub-groups, and low-, moderate- and high-frequency sub-groups. No significant differences in IQ emerged between CHR or HC cannabis users vs. non-users, or between use frequency groups. CHR late-onset users showed significantly higher IQ than CHR early-onset users. Age at onset of cannabis use was significantly and positively correlated with IQ in CHR only. Results suggest that age at onset of cannabis may be a more important factor for IQ than use current use or use frequency in CHR. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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