Impact of substance use on conversion to psychosis in youth at clinical high risk of psychosis

SCHIZOPHRENIA RESEARCH

卷:156

Article

Buchy, Lisa¹  Perkins, Diana²  Woods, Scott W.³  Liu, Lu¹  Addington, Jean¹ 

[1] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB T2N 4Z6, Canada

[2] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[3] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

关键词: Alcohol;    Cannabis;    Prodrome;    Psychosis;    Substance use;    Tobacco;   

DOI  :  10.1016/j.schres.2014.04.021

来源: Elsevier

【 摘 要 】

Elevated rates of substance use (alcohol, tobacco, cannabis) have been reported in people at clinical high risk (CHR) of developing psychosis and there is some evidence that substance use may be higher in those who convert to a psychosis compared to non-converters. However little is known about the predictive value of substance use on risk of conversion to psychosis in those at CHR of psychosis. In the current study, 170 people at CHR of psychosis were assessed at baseline on severity of alcohol, tobacco and cannabis using the Alcohol and Drug Use Scale. Participants were recruited across three sites over a four year period as part of the Enhancing the Prospective Prediction of Psychosis (PREDICT) study. Predictors of conversion to psychosis were examined using Cox proportional hazards models. Results revealed that low use of alcohol, but neither cannabis use nor tobacco use at baseline, contributed to the prediction of psychosis in the CHR sample. Prediction algorithms incorporating combinations of additional baseline variables known to be associated with psychotic conversion may result in increased predictive power compared with substance use alone. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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