Prospective memory in schizophrenia: A meta-analysis of comparative studies

SCHIZOPHRENIA RESEARCH

卷:212

Article

Zhou, Fu-Chun^1,2,3  Zheng, Wei⁴  Lu, Li⁵  Wang, Yuan-Yuan^5,6  Ng, Chee H.⁷  Ungvari, Gabor S.^8,9  Li, Jun^10,11  Xiang, Yu-Tao⁵ 

[1] Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China

[3] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China

[4] Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Guangdong, Peoples R China

[5] Univ Macau, Fac Hlth Sci, Inst Translat Med, Unit Psychiat, Macau, Peoples R China

[6] De Montfort Univ, Fac Hlth & Life Sci, Leicester, Leics, England

[7] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia

[8] Univ Notre Dame Australia, Fremantle, WA, Australia

[9] Univ Western Australia, Sch Med, Div Psychiat, Perth, WA, Australia

[10] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China

[11] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China

关键词: Schizophrenia;    Prospective memory;    Cognitive impairment;    Meta-analysis;   

DOI  :  10.1016/j.schres.2019.08.010

来源: Elsevier

【 摘 要 】

Background: Impairment of prospective memory (PM) in schizophrenia has gained increasing attention. This meta-analysis systematically examined PM impairment in schizophrenia. Methods: Both English (PubMed, PsycINFO, EMBASE, and Cochrane Library) and Chinese (WanFang, Chinese Biomedical and China Journal Net databases) databases were systematically searched from their inception until August 14, 2017. Case-control studies of PM in schizophrenia were included. Standardized mean differences (SMDs) and their 95% confidence interval (CI) were calculated using the random-effects model. Results: Twenty-nine case-control studies (n = 2492) were included in the analyses. The overall and three subtypes of PM were compared between patients with schizophrenia (n = 1284) and healthy controls (n = 1208). Compared to healthy controls, patients performed significantly poorer in overall (SMD = -1.125), time-based (SMD = -1.155), event-based (SMD = -1.068), and activity-based PM (SMD = -0.563). Subgroup analyses revealed significant differences between older and younger patients (SMD = -1.398 vs. -0.763), higher male predominance and no sex predominance (SMD = -1.679 vs. -0.800), lower and higher education level (SMD = -1.373 vs.-0.637), chronic and first-episode patients (SMD = -1.237 vs. -0.641) and between eco-valid and dual-task laboratory measurements (SMD = -1.542 vs. -0.725) regarding overall PM. Meta-regression analysis showed that higher negative symptom score was significantly associated with more severe overall PM impairment in patients (P = 0.022). Conclusions: In this meta-analysis the overall PM and all its subtypes, particularly the time-based PM, were significantly impaired in schizophrenia. (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

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