Smoking status as a potential confound in the BOLD response of patients with schizophrenia

SCHIZOPHRENIA RESEARCH

卷:104

Article

Leyba, Leonard^1,2  Mayer, Andrew R.^1,3  Gollub, Randy L.^1,4  Andreasen, Nancy C.^1,5  Clark, Vincent P.^1,2,6 

[1] Mind Res Network, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Hlth Sci Ctr, Dept Neurosci, Albuquerque, NM 87131 USA

[3] Univ New Mexico, Hlth Sci Ctr, Dept Neurol, Albuquerque, NM 87131 USA

[4] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA 02129 USA

[5] Univ Iowa, Roy J & Lucille A Carver Col Med, Dept Psychiat, Iowa City, IA USA

[6] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA

关键词: schizophrenia;    functional magnetic resonance imaging;    cigarette;    nicotine;    atherosclerosis;    vascular disease;   

DOI  :  10.1016/j.schres.2008.06.008

来源: Elsevier

【 摘 要 】

Background: Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients. Methods: The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers. Results: Group differences in activation magnitude and spatial extent were non-significant. Conclusions: Typical smoking histories in schizophrenia patients do not significantly confound FMRI results ill simple sensorimotor tasks when patient demographics are carefully controlled. (C) 2008 Elsevier B.V. All rights reserved.

【 授权许可】

Free