Event-related potential abnormalities in schizophrenia: A failure to gate in salient information?

SCHIZOPHRENIA RESEARCH

卷:113

Article

Brenner, Colleen A.¹  Kieffaber, Paul D.²  Clementz, Brett A.^3,4  Johannesen, Jason K.⁵  Shekhar, Anantha^6,8  O'Donnell, Brian F.^7,8  Hetrick, William P.^7,8 

[1] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada

[2] Coll William & Mary, Dept Psychol, Williamsburg, VA 23185 USA

[3] Univ Georgia, Dept Psychol, Bioimaging Res Ctr, Athens, GA 30602 USA

[4] Univ Georgia, Dept Neurosci, Bioimaging Res Ctr, Athens, GA 30602 USA

[5] Yale Univ, Sch Med, Dept Psychiat, VA Connecticut Hlth Care Syst,Psychol Serv, West Haven, CT 06516 USA

[6] Indiana Univ, Sch Med, Dept Psychiat, Inst Psychiat Res, Indianapolis, IN 46202 USA

[7] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[8] Larue D Carter Hosp, Indianapolis, IN 46220 USA

关键词: Sensory gating;    P50;    Schizophrenia;    ERP;    Power;    Salience;   

DOI  :  10.1016/j.schres.2009.06.012

来源: Elsevier

【 摘 要 】

Sensory gating refers to the central nervous system's ability to filter sensory inputs, and can be measured by comparing the suppression of event-related brain potential (ERP) amplitudes in paired auditory stimulus procedure. Poor gating scores in schizophrenia may be caused by: abnormal responses to the first (SI), the second (S2) or both of the paired stimuli. However since S1 and S2 responses may index separate psychological phenomenon, corresponding to the ability to gate in and gate out sensory stimuli respectively, the precise mechanism affected in schizophrenia remains unclear. To examine the extent to which saliency processing abnormalities may contribute to SI response deficits, standard and rare (15% probability paired stimuli were presented to 21 participants with schizophrenia and 22 healthy control! P50 and N100 ERP amplitude as well as low, beta and gamma frequency power were measure to examine the time course and relative contributions of oscillatory activity affecting auditor processing in schizophrenia. In this study, schizophrenia patients exhibited less evoked beta power (12-20 Hz) in response to salient stimuli at SI, and lower N100 amplitude in response to all SI stimuli. No group differences were found in the low, beta 2 (20-30 Hz), or gamma frequency ranges. These findings suggest aberrant sensory processing during stages of stimulu evaluation and saliency detection in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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