Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study

SCHIZOPHRENIA RESEARCH

卷:204

Article

Lally, John^1,2,3,4,15  Ajnakina, Olesya^1,15  Singh, Nidhita^1,15  Gardner-Sood, Poonam^1,15  Stubbs, Brendon^5,6  Stringer, Dominic⁷  Di Forti, Malta⁸  David, Anthony S.^1,9,15  Smith, Shubulade^10,11  Murray, Robin M.^1,12,15  Howes, Oliver D.^1,13,15  Gaughran, Fiona^1,14,15 

[1] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England

[2] Beaumont Hosp, Dept Psychiat, Royal Coll Surg Ireland, Dublin, Ireland

[3] St Vincents Univ Hosp, Univ Coll Dublin, Sch Med & Med Sci, Dept Psychiat, Dublin, Ireland

[4] St Vincents Hosp Fairview, Dept Psychiat, Dublin, Ireland

[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychol Med Dept, London SE5 8AF, England

[6] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London SE5 8AZ, England

[7] Kings Coll London, Dept Biostat & Hlth Informat, Inst Psychiat Psychol & Neurosci, London, England

[8] Kings Coll London, Dept Social Genet & Dev Psychiat SGDP, Inst Psychiat Psychol & Neurosci, London, England

[9] NHS Fdn Trust & Kings Coll London, Mental Hlth Biomed Res Ctr South London & Maudsle, NIHR, London, England

[10] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London, England

[11] South London & Maudsley NHS Fdn Trust, Forens Intens Care Serv, London, England

[12] Univ Palermo, Dept Psychiat Expt Biomed & Clin Neurosci BIONEC, Palermo, Italy

[13] MRC Clin Sci Ctr, Imperial Hammersmith Campus, London, England

[14] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England

[15] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychosis Studies, PO63,De Crespigny Pk, London SE5 8AF, England

关键词: 25-hydroxyvitamin D (25(OH)D);    FEP;    Schizophrenia;    Longitudinal;    Negative symptoms;    Cognitive;    Psychosis;   

DOI  :  10.1016/j.schres.2018.08.011

来源: Elsevier

【 摘 要 】

Background: There is a paucity of longitudinal research investigating vitamin D in people with early psychosis. Method: Vitamin D levels were measured in 168 patients (64% (n = 108) male, mean age 29.3 (9.8) years) with first episode psychosis (FEP), along with measures of clinical state at baseline and at 12 months follow up. We assessed the a) cross sectional, and; b) longitudinal relationships between continuous and categorical 25-hydroxyvitamin D (25(OH)D) levels and clinical symptoms at first contact for psychosis and at 12 months. Results: In FEP, 80% (n = 134) at baseline, and 76% at 12 months follow up, had suboptimal vitamin D levels (<20 ng/ml). Suboptimal levels of 25 (OH) D at baseline were not cross-sectionally associated with clinical symptoms. Higher vitamin D levels at baseline (n = 77) were significantly associated with better visual reproduction-immediate recall (beta = 0.249, 95%CI = -0.012-0.871, p = 0.044). Higher baseline vitamin D levels were prospectively associated with lower total PANSS (beta = -0.24. 95%CI = -0.47-0.01, p = 0.04) and PANSS negative symptom scores (beta = -0.12, 95%CI = -0.23-0.01, p = 0.04) at 12 months. Conclusion: We identified a prospective association between higher baseline serum Vitamin D levels and lower total psychotic symptoms and negative symptoms of psychosis at 12 months after first contact for psychosis. The results of this study require replication in larger prospective studies, and highlight the need for large randomised trials to assess the effect of vitamin D supplementation on symptoms of psychosis in PEP. (C) 2018 Elsevier B.V. All rights reserved.

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