Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies

PSYCHIATRY RESEARCH

卷:284

Review

Brokmeier, Luisa Leonie¹  Firth, Joseph^2,3,4  Vancampfort, Davy^5,6  Smith, Lee⁷  Deenik, Jeroen^8,9  Rosenbaum, Simon^10,11  Stubbs, Brendon^12,13  Schuch, Felipe Barreto¹⁴ 

[1] Univ Konstanz, Constance, Germany

[2] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia

[3] Univ Manchester, Fac Biol, Div Psychol & Mental Hlth, Manchester, Lancs, England

[4] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[5] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium

[6] Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium

[7] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England

[8] GGz Centraal, Utrechtseweg 266, NL-3818 EW Amersfoort, Netherlands

[9] Maastricht Univ, Sch Mental Hlth & Neurosci, Minderbroedersberg 4-6, NL-6211 LK Maastricht, Netherlands

[10] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[11] Black Dog Inst, Sydney, NSW, Australia

[12] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England

[13] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England

[14] Univ Fed Santa Maria, Dept Sports Methods & Tech, Santa Maria, RS, Brazil

关键词: Physical activity;    Schizophrenia;    Psychosis;    Protective;    Risk factor;    Longitudinal;    incidence;   

DOI  :  10.1016/j.psychres.2019.112675

来源: Elsevier

【 摘 要 】

Longitudinal prospective cohorts have suggested that physical activity (PA) may be a protective factor against psychosis and schizophrenia. However, no meta-analysis has been conducted. The study aims to examine the prospective relationship between PA and incident psychosis/schizophrenia. Major databases were searched from inception to July 2019 for prospective studies that calculated the odds ratio (OR) or the adjusted odds ratio (AOR) of incident psychosis/schizophrenia in people with higher PA against people with lower PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted, for OR and AOR, separately. Across 4 cohorts (N = 30,025 median males = 50%, median follow-up = 32 years), people with high self-reported PA (versus low PA) were at reduced odds of developing psychosis/schizophrenia (OR = 0.73, 95%CI 0.532 to 0.995, p = 0.047). Analysis including 2 cohorts presenting AOR were not statistically significant (AOR = 0.59, 95%CI 0.253 to 1.383, p = 0.226). Overall study quality was high (mean NOS = 7.0). The literature on the topic is scarce, whilst crude analysis suggests that PA may be a protective factor against the emergence of psychosis/schizophrenia, but when adjusting for covariates, the association is no longer significant. Further studies with objective physical activity and adjustment for confounders are needed.

【 授权许可】

Free