A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China

SCHIZOPHRENIA RESEARCH

卷:197

Article

Li, Huijun¹  Zhang, TianHong²  Xu, LiHua²  Tang, YingYing²  Cui, HuiRu²  Wei, YanYan²  Tang, XiaoChen²  Woodberry, Kristen A.³  Shapiro, Daniel I.⁴  Li, ChunBo²  Seidman, Larry J.³  Wang, JiJun² 

[1] Florida A&M Univ, Dept Psychol, 501 Orr Dr, Tallahassee, FL 32307 USA

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China

[3] Harvard Med Sch, Dept Psychiat, Beth Israel Deaconess Med Ctr, 75 Fenwood Rd, Boston, MA 02115 USA

[4] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

关键词: Clinical high risk;    Prodromal psychosis;    Conversion rates;   

DOI  :  10.1016/j.schres.2017.11.029

来源: Elsevier

【 摘 要 】

Objective: In a previous epidemiological study, we reported on the ascertainment and outcomes of clinical high risk (CHR) individuals at the Shanghai Mental Health Center (SMHC, 2011 cohort). The current study compares demographic and clinical characteristics, including conversion rates, of this sample with a subsequently recruited, independent CHR sample and with published data from western samples. Method: A newsample of 100 CHR subjects (2013 cohort) was selected based on screening and semi-structured interviews. Both studies used the Structured Interview for Prodromal Syndromes (SIPS) for CHR assessment and conducted a naturalistic two-year follow-up. The two cohortswere compared on conversion rates, demographic and clinical characteristics, psychosis risk symptoms, and risk factors for psychotic conversion. Results: Ninety one (91%) of the 2013 cohort subjects completed the clinical two-year follow-up and 25 (27.5% of the 91) converted to a psychotic disorder over the follow-up period. A comparison of conversions to full psychosis between the 2013 and the 2011 cohorts showed no significant difference in time to conversion (Pairwise comparison:chi(2) - 0.3, p - 0.562). Both cohort studies showed that CHR subjects with more severe clinical symptoms at baseline and decline in functioning were more likely to convert to psychosis. Conclusions: Conversion rates in this new, independent Chinese sample are similar to those reported in non-Chinese samples and to the 2011 cohort. Future research is needed to examine whether the implementation of early intervention for CHR/prodromal symptoms reduces the risk of psychosis and decreases the conversion rate. (C) 2017 Elsevier B.V. All rights reserved.

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