Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome

SCHIZOPHRENIA RESEARCH

卷:118

Article

Stoddard, Joel^1,2  Niendam, Tara^1,3  Hendren, Robert⁴  Carter, Cameron^1,3  Simon, Tony J.^1,2 

[1] UCDHS, Dept Psychiat & Behav Sci, Davis, CA USA

[2] UCDHS, Med Invest Neurodev Disorders MIND Inst, Davis, CA USA

[3] UCDHS, Imaging Res Ctr, Davis, CA USA

[4] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

关键词: Chromosome 22q11.2 deletion syndrome;    VCFS;    Schizophrenia;    Prodromal psychosis;    Clinical-high-risk psychosis;   

DOI  :  10.1016/j.schres.2009.12.011

来源: Elsevier

【 摘 要 】

Thirty percent of individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder, particularly schizophrenia. We assessed attenuated positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 adolescents with 22q11.2DS (median age 15.1 years) using the Structured Interview for Prodromal Symptoms (SIPS). Two participants met criteria for the Attenuated Positive Symptom Syndrome, while nine participants (45%) experienced positive symptoms rated in the moderate to severe and psychotic range on the SIPS. Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free