Does diffusion MRI tell us anything about the white matter? An overview of methods and pitfalls

SCHIZOPHRENIA RESEARCH

卷:161

Review

O'Donnell, Lauren J.¹  Pasternak, Ofer² 

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Psychiat, Boston, MA 02115 USA

关键词: Diffusion MRI;    White matter;    Tractography;    Non-specificity;    Clinical research;    Neuroimaging;   

DOI  :  10.1016/j.schres.2014.09.007

来源: Elsevier

【 摘 要 】

One key pitfall in diffusion magnetic resonance imaging (dMRI) clinical neuroimaging research is the challenge of understanding and interpreting the results of a complex analysis pipeline. The sophisticated algorithms employed by the analysis software, combined with the relatively non-specific nature of many diffusion measurements, lead to challenges in interpretation of the results. This paper is aimed at an intended audience of clinical researchers who are learning about dMRI or trying to interpret dMRI results, and who may be wondering Does dMRI tell us anything about the white matter? We present a critical review of dMRI methods and measures used in clinical neuroimaging research, focusing on the most commonly used analysis methods and the most commonly reported measures. We describe important pitfalls in every section, and provide extensive references for the reader interested in more detail. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free