Diminished auditory sensory gating during active auditory verbal hallucinations

SCHIZOPHRENIA RESEARCH

卷:188

Article

Thoma, Robert J.^1,2,3,4  Meier, Andrew⁵  Houck, Jon^2,3,4  Clark, Vincent P.^2,3,4,6  Lewine, Jeffrey D.^2,3  Turner, Jessica^2,3,7  Calhoun, Vince^1,2,3,8  Stephen, Julia^2,3 

[1] 1 Univ New Mexico, Dept Psychiat, MSC 09 5030, Albuquerque, NM 87131 USA

[2] Mind Res Network, 1101 Yale NE, Albuquerque, NM 87131 USA

[3] Lovelace Family Co, 1101 Yale NE, Albuquerque, NM 87131 USA

[4] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA

[5] Univ New Mexico, Dept Biol, PREP Program, Albuquerque, NM 87131 USA

[6] Univ New Mexico, Psychol Clin Neurosci Ctr, Albuquerque, NM 87131 USA

[7] Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA

[8] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA

关键词: Auditory sensory gating;    Hallucinations;    Auditory verbal hallucinations;    Schizophrenia;    EEG;    ERP;    Auditory processing;   

DOI  :  10.1016/j.schres.2017.01.023

来源: Elsevier

【 摘 要 】

Auditory sensory gating, assessed in a paired-click paradigm, indicates the extent to which incoming stimuli are filtered, or gated, in auditory cortex. Gating is typically computed as the ratio of the peak amplitude of the event related potential (ERP) to a second click (S2) divided by the peak amplitude of the ERP to a first click (S1). Higher gating ratios are purportedly indicative of incomplete suppression of S2 and considered to represent sensory processing dysfunction. In schizophrenia, hallucination severity is positively correlated with gating ratios, and it was hypothesized that a failure of sensory control processes early in auditory sensation (gating) may represent a larger system failure within the auditory data stream; resulting in auditory verbal hallucinations (AVH). EEG data were collected while patients (N = 12) with treatment-resistant AVH pressed a button to indicate the beginning (AVH-on) and end (AVH-off) of each AVH during a paired click protocol. For each participant, separate gating ratios were computed for the P50, N100, and P200 components for each of the AVH-off and AVH-on states. AVH trait severity was assessed using the Psychotic Symptoms Rating Scales AVH Total score (PSYRATS). The results of a mixed model ANOVA revealed an overall effect for AVH state, such that gating ratios were significantly higher during the AVH-on state than during AVH-off for all three components. PSYRATS score was significantly and negatively correlated with N100 gating ratio only in the AVH-off state. These findings link onset of AVH with a failure of an empirically-defined auditory inhibition system, auditory sensory gating, and pave the way for a sensory gating model of AVH. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

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