The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations

Frontiers in Human Neuroscience

卷:7

Else-Marie eLøberg¹  Rune A. eKroken¹  René eWesterhausen¹  Kenneth eHugdahl¹  Einar eVedul-Kjelsås²  Bodil eKråkvik³  Josef J. Bless⁴  Erik eJohnsen⁴  Liv E. Falkenberg⁴  Kristiina eKompus⁴  Frank eLarøi⁵ 

[1] Haukeland University Hospital;

[2] NTNU;

[3] St.Olavs University Hospital;

[4] University of Bergen;

[5] University of Liège;

关键词: Schizophrenia;    Auditory verbal hallucinations;    primary auditory cortex;    Auditory Attention;    non-clinical;   

DOI  :  10.3389/fnhum.2013.00144

来源: DOAJ

【 摘 要 】

Auditory verbal hallucinations (AVHs) are a subjective experience of "hearing voices" in the absence of corresponding physical stimulation in the environment. The most remarkable feature of AVHs is their perceptual quality, that is, the experience is subjectively often as vivid as hearing an actual voice, as opposed to mental imagery or auditory memories. This has lead to propositions that dysregulation of the primary auditory cortex (PAC) is a crucial component of the neural mechanism of AVHs. One possible mechanism by which the PAC could give rise to the experience of hallucinations is aberrant patterns of neuronal activity whereby the PAC is overly sensitive to activation arising from internal processing, while being less responsive to external stimulation. In this paper, we review recent research relevant to the role of the PAC in the generation of AVHs. We present new data from a functional magnetic resonance imaging (fMRI) study, examining the responsivity of the left and right PAC to parametrical modulation of the intensity of auditory verbal stimulation, and corresponding attentional top-down control in non-clinical participants with AVHs, and non-clinical participants with no AVHs. Non-clinical hallucinators showed reduced activation to speech sounds but intact attentional modulation in the right PAC. Additionally, we present data from a group of schizophrenia patients with AVHs, who do not show attentional modulation of left or right PAC. The context-appropriate modulation of the PAC may be a protective factor in non-clinical hallucinations.

【 授权许可】

Unknown