The schizophrenia and bipolar twin study in Sweden (STAR)

SCHIZOPHRENIA RESEARCH

卷:204

Article

Johansson, Viktoria^1,2,3  Hultman, Christina M.¹  Kizling, Isabelle¹  Martinsson, Lennart¹  Borg, Jacqueline^2,3,4  Hedman, Anna¹  Cannon, Tyrone D.^5,6 

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Norra Stn Gatan 69, SE-11364 Stockholm, Sweden

[3] Stockholm Cty Council, Stockholm Hlth Care Serv, Norra Stn Gatan 69, SE-11364 Stockholm, Sweden

[4] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[5] Yale Univ, Dept Psychol, New Haven, CT USA

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

关键词: Psychiatry;    Etiology;    Gene-environment interaction;    Endophenotype;    Biomarker;    Neuroimaging;   

DOI  :  10.1016/j.schres.2018.08.001

来源: Elsevier

【 摘 要 】

The schizophrenia and bipolar twin study in Sweden (STAR) is a large nation-wide cohort of monozygotic (MZ) and dizygotic (DZ) same-sex twins with schizophrenia or bipolar disorder and healthy control pairs, extensively characterized with brain imaging, neuropsychological tests, biomarkers, genetic testing, psychiatric symptoms and personality traits. The purpose is to investigate genetic and environmental mechanisms that give rise to schizophrenia and bipolar disorder as well as the intermediate phenotypes. This article describes the design, recruitment, data collection, measures, collected twins' characteristics, diagnostic procedures as well as ongoing and planned analyses. Identification of biomarkers, genetic and epigenetic variation and the development of specific and common endophenotypes for schizophrenia and bipolar disorder are potential gains from this cohort. (C) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

Free