Unilamellar polyion complex vesicles (PICsomes) with tunable permeabilities for macromolecular solutes with different shapes and sizes

POLYMER

卷:133

Article

Mutaf, Omer F.¹  Anraku, Yasutaka¹  Kishimura, Akihiro^2,3  Kataoka, Kazunori^4,5 

[1] Univ Tokyo, Grad Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan

[2] Kyushu Univ, Fac Engn, Nishi Ku, 744 Moto Oka, Fukuoka 8190395, Japan

[3] Kyushu Univ, Ctr Mol Syst, Nishi Ku, 744 Moto Oka, Fukuoka 8190395, Japan

[4] Univ Tokyo, Policy Alternat Res Inst, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[5] Kawasaki Inst Ind Promot, Innovat Ctr NanoMed, Kawasaki Ku, 3-25-14 Tonomachi, Kawasaki, Kanagawa 2100821, Japan

关键词: Nanomembrane;    Polyion complexes;    Permeability;    Block copolymer self-assembly;    Controlled release;   

DOI  :  10.1016/j.polymer.2017.10.062

来源: Elsevier

【 摘 要 】

Polyion complex vesicles (PICsomes) are characterized by their unique three-layered semipermeable nanomembrane structures, in which a unilamellar PIC layer is sandwiched by poly(ethylene glycol) layers, and have gathered much attention as nano-scaled drug vehicles. Herein, the crosslinking degree of the nanomembrane in the PICsome was controlled systematically for the first time. Permeability of the PICsome nanomembrane was evaluated through a kinetic study of the release of macromolecular cargoes from the PICsome. The degree of crosslinking in the nanomembrane successfully regulated the release behavior. Moreover, the shape and size of the macromolecular solutes were found to be critical factors determining their transport from the inner aqueous phase of the PICsome to the external environment. The results indicate that the unique three-layered structure of PICsome membranes plays a key role in modulating solute transport. These findings will provide a rational strategy for the development of nanomembrane-based controlled-release systems. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free