Thermo-mechanical properties of semi-degradable Poly(β-amino ester)-co-methyl methacrylate networks under simulated physiological conditions

POLYMER

卷:52

Article

Safranski, David L.^1,2  Crabtree, Jacob C.³  Huq, Yameen R.⁴  Gall, Ken^2,5 

[1] MedShape Solut, Atlanta, GA 30318 USA

[2] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, WH Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[4] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

[5] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA

关键词: Poly(beta-amino ester);    Degradable;    Toughness;   

DOI  :  10.1016/j.polymer.2011.08.033

来源: Elsevier

【 摘 要 】

Poly(beta-amino ester) networks are being explored for biomedical applications, but they may lack the mechanical properties necessary for long term implantation. The objective of this study is to evaluate the effect of adding methyl methacrylate on networks' mechanical properties under simulated physiological conditions. The networks were synthesized in two parts: (1) a biodegradable crosslinker was formed from a diacrylate and amine, (2) and then varying concentrations of methyl methacrylate were added prior to photopolymerizing the network. Degradation rate, mechanical properties, and glass transition temperature were studied as a function of methyl methacrylate composition. The crosslinking density played a limited role on mechanical properties for these networks, but increasing methyl methacrylate concentration improved the toughness by several orders of magnitude. Under simulated physiological conditions, networks showed increasing toughness or sustained toughness as degradation occurred. This work establishes a method of creating degradable networks with tailorable toughness while undergoing partial degradation. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free