Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study

BioMedical Engineering OnLine

Hazibullah Waizy²  Christina Stukenborg-Colsman²  Robert Schavan¹  Ulrike Kreimeyer²  Yvonne Noll²  Julia Diekmann²  Andreas Weizbauer²  Kerstin Radtke²  Henning Windhagen² 

[1]Syntellix AG, Schiffgraben 11, 30159 Hannover, Germany

[2]Department of Orthopaedic Surgery, Hannover Medical School, Anna-von-Borries-Str.1-7, 30625 Hannover, Germany

关键词: Osteosynthesis;    Hallux valgus;    Degradable;    Magnesium;   

Others  :  797758
DOI  :  10.1186/1475-925X-12-62

 received in 2013-04-08, accepted in 2013-06-25,  发布年份 2013

【 摘 要 】

Purpose

Nondegradable steel-and titanium-based implants are commonly used in orthopedic surgery. Although they provide maximal stability, they are also associated with interference on imaging modalities, may induce stress shielding, and additional explantation procedures may be necessary. Alternatively, degradable polymer implants are mechanically weaker and induce foreign body reactions. Degradable magnesium-based stents are currently being investigated in clinical trials for use in cardiovascular medicine. The magnesium alloy MgYREZr demonstrates good biocompatibility and osteoconductive properties. The aim of this prospective, randomized, clinical pilot trial was to determine if magnesium-based MgYREZr screws are equivalent to standard titanium screws for fixation during chevron osteotomy in patients with a mild hallux valgus.

Methods

Patients (n=26) were randomly assigned to undergo osteosynthesis using either titanium or degradable magnesium-based implants of the same design. The 6 month follow-up period included clinical, laboratory, and radiographic assessments.

Results

No significant differences were found in terms of the American Orthopaedic Foot and Ankle Society (AOFAS) score for hallux, visual analog scale for pain assessment, or range of motion (ROM) of the first metatarsophalangeal joint (MTPJ). No foreign body reactions, osteolysis, or systemic inflammatory reactions were detected. The groups were not significantly different in terms of radiographic or laboratory results.

Conclusion

The radiographic and clinical results of this prospective controlled study demonstrate that degradable magnesium-based screws are equivalent to titanium screws for the treatment of mild hallux valgus deformities.

【 授权许可】

   
2013 Windhagen et al.; licensee BioMed Central Ltd.

【 图 表 】

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