Investigating the atmospheric pressure plasma jet modification of a photo-crosslinkable hydrogel

POLYMER

卷:192

Article

Hamouda, Ines^1,2,3  Labay, Cedric^1,2,3  Ginebra, Maria Pau^1,2,3,4  Nicol, Erwan⁵  Canal, Cristina^1,2,3 

[1] Tech Univ Catalonia UPC, Dept Mat Sci & Met, Biomat Biomech & Tissue Engn Grp, C Eduard Maristany 10-14, Barcelona 08019, Spain

[2] UPC, Barcelona Res Ctr Multiscale Sci & Engn, Barcelona, Spain

[3] UPC, Res Ctr Biomed Engn CREB, Barcelona, Spain

[4] Inst Bioengn Catalonia, C Baldiri & Reixach 10-12, Barcelona 08028, Spain

[5] Le Mans Univ, Inst Mol & Mat Mans, UMR CNRS 6283, Ave Olivier Messiaen, F-72085 Le Mans 9, France

关键词: Atmospheric pressure plasma jet;    Photo-crosslinking;    Polymer solution;    Hydrogel;    Self-assembly;   

DOI  :  10.1016/j.polymer.2020.122308

来源: Elsevier

【 摘 要 】

Atmospheric pressure plasma jets (APPJ) have great potential in wound healing, bacterial disinfection and in cancer therapy. Recent studies pointed out that hydrogels can be used as screens during APPJ treatment, or even be used as reservoirs for reactive oxygen and nitrogen species generated by APPJ in liquids. Thus, novel applications are emerging for hydrogels which deserve fundamental exploration of the possible modifications undergone by the polymers in solution due to the reactivity with plasmas. Here we investigate the possible modifications occurred by APPJ treatment of an amphiphilic poly(ethylene oxide)-based triblock copolymer (tPEO) photo-crosslinkable hydrogel. While APPJ treatments lead to a certain degradation of the self-assembly of the polymeric chains at low concentrations (<2 g/L), at the higher concentrations required to form a hydrogel (>2 g/L), the polymeric chains are unaffected by APPJ and the hydrogel forming ability is kept. APPJ treatments induced a pre-crosslinking of the network with an increase of the mechanical properties of the hydrogel. Overall, the small modifications induced allow thinking of polymer solutions with hydrogel forming ability a new platform for several applications related to plasma medicine, and thus, with potential in different therapies.

【 授权许可】

Free