Fabrication, structure and properties of three-dimensional biodegradable poly(glycerol sebacate urethane) scaffolds

POLYMER

卷:122

Article

Frydrych, Martin¹  Chen, Biqiong¹ 

[1] Univ Sheffield, Dept Mat Sci & Engn, Mappin St, Sheffield S1 3JD, S Yorkshire, England

关键词: Bioelastomer;    Tissue scaffold;    Mechanical properties;    Soft tissue engineering;   

DOI  :  10.1016/j.polymer.2017.06.064

来源: Elsevier

【 摘 要 】

Large, three-dimensional, porous poly(glycerol sebacate urethane) (PGSU) scaffolds were fabricated via a solvent-based synthesis approach followed by freeze-drying and curing. The scaffolds showed highly interconnected open-cell structures with porosities and pore sizes in the ranges of 77-88% and 55 74 gm, respectively. The mechanical properties were measured in dry and hydrated states during quasi static and cyclic tensile and compression tests. Hydrated PGSU scaffolds featured tensile Young moduli, ultimate tensile strengths and elongations at break in the ranges of 29-32 kPa, 12-19 kPa and 50-57%, respectively. In vitro degradation tests of the PGSU scaffolds presented adjustable degradation rates and mass losses of 10-16% and 30-62% without and with the presence of lipase enzyme in 112 days, respectively. This work illustrates that the large and porous PGSU scaffolds, characterised with flexible and soft mechanical properties, as well as long-term stability and adjustable degradation kinetics, have high potential for applications in soft tissue engineering. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free