Versatile surface biofunctionalization of poly(ethylene terephthalate) by interpenetrating polymerization of a butynyl monomer followed by Click Chemistry

POLYMER

卷:53

Article

Li, Lingdong¹  Zhao, Nan¹  Liu, Song¹ 

[1] Univ Manitoba, Fac Human Ecol, Dept Text Sci, Winnipeg, MB R3T 2N2, Canada

关键词: Interpenetrating polymer network;    Surface biofunctionalization;    Antibacterial activity;   

DOI  :  10.1016/j.polymer.2011.11.036

来源: Elsevier

【 摘 要 】

Biofunctionalization of poly(ethylene terephthalate) (PET) is crucial to its medical and biomedical applications such as surgical drapes, vascular grafts and ligament prostheses. To furnish PET with an alkynyl handle, N-(2-methylbut-3-yn-2-yl)acrylamide (MBAA) underwent photo-initiated copolymerization with N,N'-methylenebisacrylamide (MBA) in methanol-swollen PET surface to form a 3-dimensional interpenetrating network (IPN). The alkynyl handle terminated surface was denoted as PMBAA-PET. A region-selective modification could be achieved using an engraved mask during the photo-initiated copolymerization. Several functional azides including dansyl-azide 1, azido-5,5dimethyl-hydantoin analog 2, per-azido-beta-cyclodextrin (per-azido-beta-CD) and azido-Bovine Serum Albumin (BSA-N-3), were successfully bonded onto PMBAA-PET surface via Huisgen 1,3-dipolar cycloaddition. Kinetic study of the heterogeneous click reaction between PMBAA-PET and 1 was investigated using X-ray photoelectron spectroscopy (XPS) and elemental analysis. PMBAA-PET was rendered with effective biocidal activity against a healthcare-associated methicilin-resistant Staphylococcus aureus (HA-MRSA) and a multi-drug-resistant Escherichia coli (MDR-E. coli) after 2 was conferred. Meanwhile, accessible CD cavity was determined and the amount of covalently immobilized BSA protein was also quantified after the respective click linkages of per-azido-beta-CD and BSA-N-3 on PMBAA-PET surface were established. (C) 2011 Elsevier Ltd. All rights reserved.

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