Injury mechanisms in acute intracerebral hemorrhage

NEUROPHARMACOLOGY

卷:134

Review

Wilkinson, D. Andrew¹  Pandey, Aditya S.¹  Thompson, B. Gregory¹  Keep, Richard F.¹  Hua, Ya¹  Xi, Guohua¹ 

[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

关键词: Intracerebral hemorrhage;    Thrombin;    Iron;    Brain edema;    Hypertension;    Hematoma;   

DOI  :  10.1016/j.neuropharm.2017.09.033

来源: Elsevier

【 摘 要 】

Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled 'Cerebral lschemia'. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free