Converging vulnerability factors for compulsive food and drug use

NEUROPHARMACOLOGY

卷:196

Review

Serafine, Katherine M.¹  O'Dell, Laura E.¹  Zorrilla, Eric P.^2,3 

[1] Univ Texas El Paso, Dept Psychol, 500 W Univ Ave, El Paso, TX 79968 USA

[2] Scripps Res Inst, Dept Mol Med, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Neurosci, La Jolla, CA 92037 USA

关键词: Obesity;    Addiction;    Substance use disorder;    Binge eating disorder;    Cross-vulnerability;    Comorbidity;   

DOI  :  10.1016/j.neuropharm.2021.108556

来源: Elsevier

【 摘 要 】

Highly palatable foods and substance of abuse have intersecting neurobiological, metabolic and behavioral ef-fects relevant for understanding vulnerability to conditions related to food (e.g., obesity, binge eating disorder) and drug (e.g., substance use disorder) misuse. Here, we review data from animal models, clinical populations and epidemiological evidence in behavioral, genetic, pathophysiologic and therapeutic domains. Results suggest that consumption of highly palatable food and drugs of abuse both impact and conversely are regulated by metabolic hormones and metabolic status. Palatable foods high in fat and/or sugar can elicit adaptation in brain reward and withdrawal circuitry akin to substances of abuse. Intake of or withdrawal from palatable food can impact behavioral sensitivity to drugs of abuse and vice versa. A robust literature suggests common substrates and roles for negative reinforcement, negative affect, negative urgency, and impulse control deficits, with both highly palatable foods and substances of abuse. Candidate genetic risk loci shared by obesity and alcohol use disorders have been identified in molecules classically associated with both metabolic and motivational func-tions. Finally, certain drugs may have overlapping therapeutic potential to treat obesity, diabetes, binge-related eating disorders and substance use disorders. Taken together, data are consistent with the hypotheses that compulsive food and substance use share overlapping, interacting substrates at neurobiological and metabolic levels and that motivated behavior associated with feeding or substance use might constitute vulnerability factors for one another. This article is part of the special issue on 'Vulnerabilities to Substance Abuse'.

【 授权许可】

Free