Genetic approaches in Drosophila for the study neurodevelopmental disorders

NEUROPHARMACOLOGY

卷:68

Review

Okray, Zeynep^1,2,3  Hassan, Bassem A.^1,2,3 

[1] VIB, VIB Ctr Biol Dis, Neurogenet Lab, Louvain, Belgium

[2] Univ Louvain, Sch Med, Ctr Human Genet, Louvain, Belgium

[3] Univ Louvain, Doctoral Sch Biomed Sci, Program Mol & Dev Genet, Louvain, Belgium

关键词: Intellectual disability;    Neurodevelopmental disorders;    Drosophila genetics;   

DOI  :  10.1016/j.neuropharm.2012.09.007

来源: Elsevier

【 摘 要 】

The fruit fly Drosophila melanogaster is one of the premier genetic model organisms used in biomedical research today owing to the extraordinary power of its genetic tool-kit. Made famous by numerous seminal discoveries of basic developmental mechanisms and behavioral genetics, the power of fruit fly genetics is becoming increasingly applied to questions directly relevant to human health. In this review we discuss how Drosophila research is applied to address major questions in neurodevelopmental disorders. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free