Lateral habenula dysfunctions in Tm4sf2−/y mice model for neurodevelopmental disorder

Neurobiology of Disease

Anna Longatti¹  Mariaelvina Sala²  Luisa Ponzoni³  Sara Mazzoleni⁴  Giorgia Giansante⁵  Silvia Bassani⁵  Maria Passafaro⁵  Luca Murru⁵ 

[1] Corresponding authors at: Institute of Neuroscience, CNR, Milan 20129, Italy.;Department of Medical Biotechnology and Translational Medicine, Università di Milano, Segrate, MI 20090, Italy;NeuroMI Milan Center for Neuroscience, Università Milano-Bicocca, Milan 20126, Italy;Department of Medical Biotechnology and Translational Medicine, Università di Milano, Segrate, MI 20090, Italy;Institute of Neuroscience, CNR, Milan 20129, Italy;

关键词: Lateral habenula;    TSPAN7;    Intellectual disability;    Autism spectrum disorder;    Neurodevelopmental disorders;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mutations in the TM4SF2 gene, which encodes TSPAN7, cause a severe form of intellectual disability (ID) often comorbid with autism spectrum disorder (ASD). Recently, we found that TM4SF2 loss in mice affects cognition. Here, we report that Tm4sf2−/y mice, beyond an ID-like phenotype, display altered sociability, increased repetitive behaviors, anhedonic- and depressive-like states. Cognition relies on the integration of information from several brain areas. In this context, the lateral habenula (LHb) is strategically positioned to coordinate the brain regions involved in higher cognitive functions. Furthermore, in Tm4sf2−/y mice we found that LHb neurons present hypoexcitability, aberrant neuronal firing pattern and altered sodium and potassium voltage-gated ion channels function. Interestingly, we also found a reduced expression of voltage-gated sodium channel and a hyperactivity of the PKC-ERK pathway, a well-known modulator of ion channels activity, which might explain the functional phenotype showed by Tm4sf2−/y mice LHb neurons.These findings support Tm4sf2−/y mice as useful in modeling some ASD-like symptoms. Additionally, we can speculate that LHb functional alteration in Tm4sf2−/y mice might play a role in the disease pathophysiology.

【 授权许可】

Unknown