Long-term potentiation: Peeling the onion

NEUROPHARMACOLOGY

卷:74

Review

Nicoll, Roger A.^1,2  Roche, Katherine W.³ 

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[3] NINDS, Receptor Biol Sect, NIH, Bethesda, MD 20892 USA

关键词: NMDA receptor;    AMPA receptor;    CaMKII;    Long-term potentiation;    Synapse;   

DOI  :  10.1016/j.neuropharm.2013.02.010

来源: Elsevier

【 摘 要 】

Since the discovery of long-term potentiation (LTP), thousands of papers have been published on this phenomenon. With this massive amount of information, it is often difficult, especially for someone not directly involved in the field, not to be overwhelmed. The goal of this review is to peel away as many layers as possible, and probe the core properties of LTP. We would argue that the many dozens of proteins that have been implicated in the phenomenon are not essential, but rather modulate, often in indirect ways, the threshold and/or magnitude of LTP. What is required is NMDA receptor activation followed by CaMKII activation. The consequence of CaMKII activation is the rapid recruitment of AMPA receptors to the synapse. This recruitment is independent of AMPA receptor subunit type, but absolutely requires an adequate pool of surface receptors. An important unresolved issue is how exactly CaMKII activation leads to modifications in the PSD to allow rapid enrichment. This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free