Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats

NEUROBIOLOGY OF AGING

卷:33

Article

Molina, Doris P.^5,6  Ariwodola, Olusegun J.⁴  Linville, Constance^5,6  Sonntag, William E.^3,4  Weiner, Jeff L.⁴  Brunso-Bechtold, Judy K.^2,5,6  Adams, Michelle M.^1,2,5,6 

[1] Bilkent Univ, Dept Psychol, TR-06800 Ankara, Turkey

[2] Wake Forest Univ, Bowman Gray Sch Med, Roena Kulynych Ctr Memory & Cognit Res, Winston Salem, NC USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, Oklahoma City, OK USA

[4] Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol, Winston Salem, NC USA

[6] Wake Forest Univ, Bowman Gray Sch Med, Dept Anat, Winston Salem, NC 27103 USA

关键词: Long-term potentiation;    Paired-pulse ratios;    Input-output curves;    AMPA receptor;    NMDA receptor;   

DOI  :  10.1016/j.neurobiolaging.2011.09.014

来源: Elsevier

【 摘 要 】

Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regulates AMPA-R and NMDA-R-dependent excitatory transmission and decreases with age. Chronic GH treatment mitigates age-related cognitive decline. An in vitro CA1 hippocampal slice preparation was used to compare hippocampal excitatory transmission and plasticity in old animals treated for 6-8 months with either saline or GH. Our findings indicate that GH treatment restores NMDA-R-dependent basal synaptic transmission in old rats to young adult levels and enhances both AMPA-R-dependent basal synaptic transmission and long-term potentiation. These alterations in synaptic function occurred in the absence of changes in presynaptic function, as measured by paired-pulse ratios, the total protein levels of AMPA-R and NMDA-R subunits or in plasma or hippocampal levels of insulin-like growth factor-I. These data suggest a direct role for GH in altering age-related changes in excitatory transmission and provide a possible cellular mechanism through which GH changes the course of cognitive decline. (C) 2012 Elsevier Inc. All rights reserved.

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