Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

NEUROPHARMACOLOGY

卷:61

Review

Sidhpura, Nimish¹  Parsons, Loren H.¹ 

[1] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA

关键词: Synaptic plasticity;    Endocannabinoid;    Addiction;    Relapse;    Stress;    Affective disorder;   

DOI  :  10.1016/j.neuropharm.2011.05.034

来源: Elsevier

【 摘 要 】

Endogenous cannabinoids (eCBs) are retrograde messengers that provide feedback inhibition of both excitatory and inhibitory transmission in brain through the activation of presynaptic CBI receptors. Substantial evidence indicates that eCBs mediate various forms of short- and long-term plasticity in brain regions involved in the etiology of addiction. The present review provides an overview of the mechanisms through which eCBs mediate various forms of synaptic plasticity and discusses evidence that eCB-mediated plasticity is disrupted following exposure to a variety of abused substances that differ substantially in pharmacodynamic mechanism including alcohol, psychostimulants and cannabinoids. The possible involvement of dysregulated eCB signaling in maladaptive behaviors that evolve over long-term drug exposure is also discussed, with a particular focus on altered behavioral responses to drug exposure, deficient extinction of drug-related memories, increased drug craving and relapse, heightened stress sensitivity and persistent affective disruption (anxiety and depression). This article is part of a Special Issue entitled 'Synaptic Plasticity and Addiction'. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free