The role of fragile X mental retardation protein in major mental disorders

NEUROPHARMACOLOGY

卷:60

Review

Fatemi, S. Hossein^1,2,3  Folsom, Timothy D.¹ 

[1] Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci Res, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA

关键词: Fragile X mental retardation protein;    Brain;    Autism;    Schizophrenia;    Dendrite;    Metabotropic glutamate receptor;   

DOI  :  10.1016/j.neuropharm.2010.11.011

来源: Elsevier

【 摘 要 】

Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP plays in neuronal cells, experiments from our own laboratory that demonstrate reductions of FMRP in additional psychiatric disorders (autism, schizophrenia, bipolar disorder, and major depressive disorder), and potential therapies to ameliorate the loss of FMRP. This article is part of a Special Issue entitled 'Trends in Neuropharmacology: In Memory of Erminio Costa'. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free