Purinergic neurone-glia signalling in cognitive-related pathologies

NEUROPHARMACOLOGY

卷:104

Review

Illes, Peter¹  Verkhratsky, Alexei^2,3,4,5,6 

[1] Univ Leipzig, Rudolf Boehm Inst Pharmacol & Toxicol, D-04107 Leipzig, Germany

[2] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

[3] Basque Fdn Sci, Ikerbasque, Achucarro Ctr Neurosci, Bilbao 48011, Spain

[4] Univ Basque Country UPV EHU, Dept Neurosci, Leioa, Spain

[5] CIBERNED, Leioa, Spain

[6] Univ Nizhny Novgorod, Nizhnii Novgorod 603022, Russia

关键词: Astrocyte;    Microglia;    Oligodendrocyte;    Cognition;    Dementia;    Neurodegeneration;    Neuropsychiatric diseases;    Purinoceptors;    Purinergic signalling;   

DOI  :  10.1016/j.neuropharm.2015.08.005

来源: Elsevier

【 摘 要 】

Neuroglia, represented by astrocytes, oligodendrocytes, NG glia and microglia are homeostatic, myelinating and defensive cells of the brain. Neuroglial cells express various combinations of purinoceptors, which contribute to multiple intercellular signalling pathways in the healthy and diseased nervous system. Neurological diseases are invariably associated with profound neuroglial remodelling, which is manifest by reactive gliosis, pathological remodelling and functional atrophy of various types of glial cells. Gliopathology is disease and region specific and produces multiple glial phenotypes that may be neuroprotective or neurotoxic. In this review we summarise recent knowledge on the role of glial purinergic signalling in cognitive-related neurological diseases. This article is part of the Special Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free