Astrocytes in myelination and remyelination

NEUROSCIENCE LETTERS

卷:713

Review

Molina-Gonzalez, Irene¹  Miron, Veronique E.¹ 

[1] Univ Edinburgh, Queens Med Res Inst, Med Res Council Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland

关键词: Astrocyte;    Myelination;    Remyelination;    Oligodendrocyte;    Multiple sclerosis;    Microglia;   

DOI  :  10.1016/j.neulet.2019.134532

来源: Elsevier

【 摘 要 】

Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as important contributors to white matter health. Here, we review the roles of astrocytes in myelin formation and regeneration (remyelination), focusing on both direct interactions with oligodendrocyte lineage cells, and indirect influences via crosstalk with central nervous system resident macrophages, microglia.

【 授权许可】

Free