New insights on neurobiological mechanisms underlying alcohol addiction

NEUROPHARMACOLOGY

卷:67

Review

Cui, Changhai¹  Noronha, Antonio¹  Morikawa, Hitoshi²  Alvarez, Veronica A.³  Stuber, Garret D.^4,5  Szumlinski, Karen K.⁶  Kash, Thomas L.⁷  Roberto, Marisa⁸  Wilcox, Mark V.³ 

[1] NIAAA, Div Neurosci & Behav, NIH, Bethesda, MD 20892 USA

[2] Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, Austin, TX 78712 USA

[3] NIAAA, Lab Integrat Neurosci, NIH, Bethesda, MD 20892 USA

[4] Univ N Carolina, UNC Sch Med, Dept Psychiat, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, UNC Sch Med, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA

[6] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA

[7] Univ N Carolina, UNC Sch Med, Dept Pharmacol, Chapel Hill, NC 27599 USA

[8] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA

关键词: Alcohol;    Dependence;    Addiction;    Metaplasticity;    CRF;    VTA;    BNST;    mGluR;    Binge drinking;    Dendritic spines;   

DOI  :  10.1016/j.neuropharm.2012.09.022

来源: Elsevier

【 摘 要 】

Alcohol dependence/addiction is mediated by complex neural mechanisms that involve multiple brain circuits and neuroadaptive changes in a variety of neurotransmitter and neuropeptide systems. Although recent studies have provided substantial information on the neurobiological mechanisms that drive alcohol drinking behavior, significant challenges remain in understanding how alcohol-induced neuroadaptations occur and how different neurocircuits and pathways cross-talk. This review article highlights recent progress in understanding neural mechanisms of alcohol addiction from the perspectives of the development and maintenance of alcohol dependence. It provides insights on cross talks of different mechanisms and reviews the latest studies on metaplasticity, structural plasticity, interface of reward and stress pathways, and cross-talk of different neural signaling systems involved in binge-like drinking and alcohol dependence. Published by Elsevier Ltd.

【 授权许可】

Free