Losing your inhibition: Linking cortical GABAergic interneurons to schizophrenia

NEUROBIOLOGY OF DISEASE

卷:53

Review

Inan, Melis¹  Petros, Timothy J.²  Anderson, Stewart A.^3,4 

[1] Weill Cornell Med Coll, Dept Neurol & Neurosci, New York, NY 10065 USA

[2] NYU, Sch Med, Dept Cell Biol & Neural Sci, New York, NY 10016 USA

[3] Childrens Hosp Philadelphia, Dept Psychiat, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

关键词: Schizophrenia;    Interneurons;    Cortex;    Inhibition;    GABA;    NMDA;    Gamma oscillations;    Parvalbumin;    Somatostatin;    Neuregulin;   

DOI  :  10.1016/j.nbd.2012.11.013

来源: Elsevier

【 摘 要 】

GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of cortical function. The diverse types of cINs are classified into subgroups according to their morphology, intrinsic physiology, neurochemical markers and synaptic targeting. Recent advances in mouse genetics, imaging and electrophysiology techniques have greatly advanced our efforts to understand the role of normal cIN function and its dysfunction in neuropsychiatric disorders. In schizophrenia (SCZ), a wealth of data suggests that cIN function is perturbed, and that interneuron dysfunction may underlie key symptoms of the disease. In this review, we discuss the link between cINs and SCZ, focusing on the evidence for GABAergic signaling deficits from both SCZ patients and mouse models. (C) 2013 Elsevier Inc. All rights reserved.

【 授权许可】

Free