Neurophysiology of dystonia: The role of inhibition

NEUROBIOLOGY OF DISEASE

卷:42

Review

Hallett, Mark

关键词: Dystonia;    Physiology;    Inhibition;    Motor control;    GABA;    Surround inhibition;    Sensory function;    Sensorimotor integration;    Basal ganglia;    Transcranial magnetic stimulation;   

DOI  :  10.1016/j.nbd.2010.08.025

来源: Elsevier

【 摘 要 】

The pathophysiology of dystonia has been best studied in patients with focal hand dystonia. A loss of inhibitory function has been demonstrated at spinal, brainstem and cortical levels. Many cortical circuits seem to be involved. One consequence of the loss of inhibition is a failure of surround inhibition. and this appears to directly lead to overflow and unwanted muscle spasms. There are mild sensory abnormalities and deficits in sensorimotor integration; these also might be explained by a loss of inhibition. Increasing inhibition may be therapeutic. A possible hypothesis is that there is a genetic loss of inhibitory interneurons in dystonia and that this deficit is a substrate on which other factors can act to produce dystonia. This article is part of a Special Issue entitled Advances in dystonia. Published by Elsevier Inc.

【 授权许可】

Free