Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits

NEUROBIOLOGY OF DISEASE

卷:63

Article

Hernan, Amanda E.^1,3  Alexander, Abigail¹  Jenks, Kyle R.¹  Barry, Jeremy^1,3  Lenck-Santini, Pierre-Pascal³  Isaeva, Elena^2,3  Holmes, Gregory L.³  Scott, Rod C.^3,4 

[1] Geisel Sch Med Dartmouth, Program Expt & Mol Med Dartmouth, Dept Neurol, Lebanon, NH 03756 USA

[2] State Key Lab Mol & Cellular Biol, UA-01601 Kiev, Ukraine

[3] Univ Vermont, Coll Med, Dept Neurol Sci, Burlington, VT 05405 USA

[4] UCL, Inst Child Hlth, London WC1N 1EH, England

关键词: Pediatric epilepsy;    Interictal spikes;    Attention;    Social behavior;    Short-term plasticity;    Prefrontal cortex;   

DOI  :  10.1016/j.nbd.2013.11.012

来源: Elsevier

【 摘 要 】

There is a well-described association between childhood epilepsy and pervasive cognitive and behavioral deficits. Often these children not only have ictal EEG events, but also frequent interictal abnormalities. The precise role of these interictal discharges in cognition remains unclear. In order to understand the relationship between frequent epileptiform discharges during neurodevelopment and cognition later in life, we developed a model of frequent focal interictal spikes (IIS). Postnatal day (p) 21 rats received injections of bicuculline methiodine into the prefrontal cortex (PFC). Injections were repeated in order to achieve 5 consecutive days of transient inhibitory/ excitatory imbalance resulting in IIS. Short-term plasticity (STP) and behavioral outcomes were studied in adulthood. IIS is associated with a significant increase in STP bilaterally in the PFC. IIS rats did not show working memory deficits, but rather showed marked inattentiveness without significant alterations in motivation, anxiety or hyperactivity. Rats also demonstrated significant deficits in social behavior. We conclude that GABAergic blockade during early-life and resultant focal IIS in the PFC disrupt neural networks and are associated with long-term consequences for behavior at a time when IIS are no longer present, and thus may have important implications for ADHD and autism spectrum disorder associated with childhood epilepsy. (C) 2013 Elsevier Inc. All rights reserved.

【 授权许可】

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