Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy

NEUROBIOLOGY OF DISEASE

卷:123

Review

Dadas, Aaron¹  Janigro, Damir^1,2 

[1] Case Western Reserve Univ, Dept Physiol, Cleveland, OH 44106 USA

[2] FloTBI Inc, 4415 Euclid Ave, Cleveland, OH 44103 USA

关键词: Peripheral markers;    Blood-brain barrier;    Post-traumatic epilepsy;    Fluid biomarkers;    Traumatic brain injury;    Anti-epileptic drugs;   

DOI  :  10.1016/j.nbd.2018.06.022

来源: Elsevier

【 摘 要 】

Traumatic brain injury (TBI) accounts for approximately 16% of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for post-traumatic seizures than adults. Post-traumatic seizures are a risk factor for delayed development of epilepsy. Delayed, chronic post-traumatic epilepsy is preceded by a silent period during which therapeutic interventions may arrest, revert or prevent epileptogenesis. A number of recent review articles summarize the most important features of post-traumatic seizures and epilepsy; this review will instead focus on the link between cerebrovascular permeability, epileptogenesis and ictal events after TBI. The possibility of acting on the blood-brain barrier (BBB) and the neurovascular unit to prevent, disrupt or treat post-traumatic epilepsy is also discussed. Finally, we describe the latest quest for biomarkers of epileptogenesis which may allow for a more targeted intervention.

【 授权许可】

Free