Young-onset and late-onset Parkinson's disease exhibit a different profile of fluid biomarkers and clinical features

NEUROBIOLOGY OF AGING

卷:90

Article

Schirinzi, Tommaso^1,2  Di Lazzaro, Giulia¹  Sancesario, Giulia Maria^3,4  Summa, Susanna²  Petrucci, Simona^5,6,7  Colona, Vito Luigi¹  Bernardini, Sergio⁴  Pierantozzi, Mariangela¹  Stefani, Alessandro¹  Mercuri, Nicola Biagio^1,3  Pisani, Antonio^1,3 

[1] Univ Roma Tor Vergata, Dept Syst Med, Viale Oxford 1, I-00139 Rome, Italy

[2] IRCCS Bambino Gesu Childrens Hosp, Dept Neurosci, Rome, Italy

[3] IRCCS Santa Lucia Fdn, Dept Expt Neurosci, Rome, Italy

[4] Univ Roma Tor Vergata, Dept Expt Med & Surg, Rome, Italy

[5] Sapienza Univ Rome, Dept Clin & Mol Med, Rome, Italy

[6] S Andrea Univ Hosp, Dept Clin & Mol Med, Rome, Italy

[7] IRCCS Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy

关键词: Young-onset Parkinson's disease;    Early-onset Parkinson's disease;    Late-onset Parkinson's disease;    Aging;    Fluid biomarkers;   

DOI  :  10.1016/j.neurobiolaging.2020.02.012

来源: Elsevier

【 摘 要 】

Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-beta peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO <= 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors. In PD, AO directly correlated to either CSF lactate and tau proteins or the nonmotor symptoms scale score. Specifically, a younger AO was associated with lower levels of biomarkers and minor burden of nonmotor symptoms. Our findings indicate that clinical-biochemical features of idiopathic PD may vary depending on the AO, accounting for different profiles in YOPD and LOPD whose recognition is fundamental for further pathophysiological implications and clinical applications. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

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