Oral health conditions and cognitive functioning in middle and later adulthood

BMC Oral Health

Stefan Listl¹ 

[1] Department of Conservative Dentistry, University of Heidelberg, Heidelberg, Germany

关键词: Aging;    Chewing ability;    Cognitive functioning;   

Others  :  848331
DOI  :  10.1186/1472-6831-14-70

 received in 2014-04-03, accepted in 2014-06-10,  发布年份 2014

【 摘 要 】

Background

The purpose of the present study was to examine the impact of oral health conditions on cognitive functioning on basis of data samples from several European countries.

Methods

Secondary analyses were conducted of data from wave 2 of the Survey of Health, Ageing, and Retirement in Europe (SHARE) which includes 14 European countries and is intended to be representative of each country’s middle and later adulthood population. Information on word recall, verbal fluency, and numeracy as well as information on chewing ability and denture wearing status was available for a total of 28,693 persons aged 50+. Multivariate regression analysis was used to detect influences of oral health parameters on cognitive functioning (p < 0.05).

Results

Persons with good chewing ability or without dentures had significantly better word recall, verbal fluency, and numeracy skills than persons with chewing impairment or with dentures. The observed patterns of parameter estimates imply differential oral health impacts on numeracy compared to word recall and verbal fluency.

Conclusions

The present study provides novel large-scale epidemiological evidence supportive of an association between oral health and cognitive functioning. Future research should intend to verify the precise causal links between oral health conditions, various cognitive dimensions, and their neural correlates.

【 授权许可】

   
2014 Listl; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Teixeira FB, Pereira Fernandes Lde M, Noronha PA, Dos Santos MA, Gomes-Leal W, do Socorro Ferraz Maia C, Rodrigues Lima R: Masticatory deficiency as a risk factor for cognitive dysfunction. Int J Med Sci 2014, 11:209-214.
• [2]Hansson P, Sunnegårdh-Grönberg K, Bergdahl J, Bergdahl M, Nyberg L, Nilsson LG: Relationship between natural teeth and memory in a healthy elderly population. Eur J Oral Sci 2013, 121:333-340.
• [3]Naorungroj S, Schoenbach VJ, Beck J, Mosley TH, Gottesman RF, Alonso A, Heiss G, Slade GD: Cross-sectional associations of oral health measures with cognitive function in late middle-aged adults: a community-based study. J Am Dent Assoc 2013, 144:1362-1371.
• [4]Elsig F, Schimmel M, Duvernay E, Giannelli SV, Graf CE, Carlier S, Herrmann FR, Michel JP, Gold G, Zekry D, Müller F: Tooth loss, chewing efficiency and cognitive impairment in geriatric patients. Gerodontology 2013. doi:10.1111/ger.12079. [Epub ahead of print]
• [5]Saito Y, Sugawara N, Yasui-Furukori N, Takahashi I, Nakaji S, Kimura H: Cognitive function and number of teeth in a community-dwelling population in Japan. Ann Gen Psychiatry 2013, 12:20. BioMed Central Full Text
• [6]Ohkubo C, Morokuma M, Yoneyama Y, Matsuda R, Lee JS: Interactions between occlusion and human brain function activities. J Oral Rehabil 2013, 40:119-29.
• [7]Lexomboon D, Trulsson M, Wårdh I, Parker MG: Chewing ability and tooth loss: association with cognitive impairment in an elderly population study. J Am Geriatr Soc 2012, 60:1951-6.
• [8]Clouston SA, Brewster P, Kuh D, Richards M, Cooper R, Hardy R, Rubin MS, Hofer SM: The dynamic relationship between physical function and cognition in longitudinal aging cohorts. Epidemiol Rev 2013. Epub ahead of print
• [9]Singh-Manoux A, Kivimaki M, Glymour MM, Elbaz A, Berr C, Ebmeier KP, Ferrie JE, Dugravot A: Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. Br Med J 2012, 344:1-8.
• [10]Richards M, Shipley B, Fuhrer R, Wadsworth ME: Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study. Br Med J 2004, 328:552-557.
• [11]Allaire JC, Gamaldo A, Ayotte BJ, Sims R, Whitfield K: Mild cognitive impairment and objective instrumental everyday functioning: the everyday cognition battery memory test. J Am Geriatr Soc 2009, 57:120-125.
• [12]Burton CL, Strauss E, Bunce D, Hunter MA, Hultsch DF: Functional abilities in older adults with mild cognitive impairment. Gerontology 2009, 55:570-581.
• [13]Wolfs CA, Dirksen CD, Kessels A, Willems DC, Verhey FR, Severens JL: Performance of the EQ-5D and the EQ-5D+C in elderly patients with cognitive impairments. Health Qual Life Outcomes 2007, 5:33. BioMed Central Full Text
• [14]Perneczky R, Pohl C, Sorg C, Hartmann J, Tosic N, Grimmer T, Heitele S, Kurz A: Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome. Int J Geriatr Psychiatry 2006, 21:158-162.
• [15]Hirano Y, Obata T, Kashikura K, Nonaka H, Tachibana A, Ikehira H, Onozuka M: Effects of chewing in working memory processing. Neurosci Lett 2008, 436:189-192.
• [16]Onozuka M, Fujita M, Watanabe K, Hirano Y, Niwa M, Nishiyama K, Saito S: Mapping brain region activity during chewing: a functional magnetic resonance imaging study. J Dent Res 2002, 81:743-746.
• [17]Onozuka M, Fujita M, Watanabe K, Hirano Y, Niwa M, Nishiyama K, Saito S: Age-related changes in brain regional activity during chewing: a functional magnetic resonance imaging study. J Dent Res 2003, 82:657-660.
• [18]Ekuni D, Tomofuji T, Irie K, Azuma T, Endo Y, Kasuyama K, Morita M: Occlusal disharmony increases amyloid-β in the rat hippocampus. Neuromolecular Med 2011, 13:197-203.
• [19]Kubo KY, Iwaku F, Watanabe K, Fujita M, Onozuka M: Molarless-induced changes of spines in hippocampal region of SAMP8 mice. Brain Res 2005, 1057:191-195.
• [20]Nieder A: Counting on neurons: the neurobiology of numerical competence. Nat Rev Neurosci 2005, 6:177-90.
• [21]Milner B, Squire LR, Kandel ER: Cognitive neuroscience and the study of memory. Neuron 1998, 20:445-468.
• [22]Noble JM, Borrell LN, Papapanou PN, Elkind MS, Scarmeas N, Wright CB: Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III. J Neurol Neurosurg Psychiatry 2009, 80:1206-11.
• [23]Burks SV, Carpenter JP, Goette L, Rustichini A: Cognitive skills affect economic preferences, strategic behavior, and job attachment. PNAS 2009, 106:7745-7750.
• [24]Peters E, Västfjäll D, Slovic P, Mertz CK, Mazzocco K, Dickert S: Numeracy and decision making. Psychol Sci 2006, 17:407-13.
• [25]Börsch-Supan A, Brandt M, Hunkler C, Kneip T, Korbmacher J, Malter F, Schaan B, Stuck S, Zuber S, Central Coordination Team SHARE: Data resource profile: the survey of health, ageing and retirement in Europe (SHARE). Int J Epidemiol 2013, 42:992-1001.
• [26]Listl S, Watt RG, Tsakos G: Early life conditions, adverse life events, and chewing ability at middle and later adulthood. Am J Public Health 2014. doi:10.2105/AJPH.2014.301918 [Epub ahead of print]
• [27]Palència L, Espelt A, Cornejo-Ovalle M, Borrell C: Socioeconomic inequalities in the use of dental care services in Europe: what is the role of public coverage? Community Dent Oral Epidemiol 2014, 42:97-105.
• [28]Listl S: Income-related inequalities in dental service utilization by Europeans aged 50+. J Dent Res 2011, 90:717-23.
• [29]Listl S, Moran V, Maurer J, Faggion CM Jr: Dental service utilization by Europeans aged 50 plus. Community Dent Oral Epidemiol 2012, 40:164-74.
• [30]Listl S, Faggion CM Jr: Income-related inequalities in chewing ability of Europeans aged 50 and above. Community Dent Health 2012, 29:144-8.
• [31]Listl S: Income-related inequalities in denture-wearing by Europeans aged 50 and above. Gerodontology 2012, 29:e948-55.
• [32]Listl S: Denture wearing by individuals among the older segment of European populations. Int J Prosthodont 2012, 25:15-20.
• [33]Listl S: Chewing abilities of elderly populations in Europe. Int Dent J 2011, 61:175-8.
• [34]UNESCO: International Standard Classification of Education (ISCED 1997). URL accessed on 31/03/2014 at: http://www.unesco.org/education/information/nfsunesco/doc/isced_1997.htm webcite
• [35]Peters E, Hibbard J, Slovic P, Dieckmann N: Numeracy skill and the communication, comprehension, and use of risk-benefit information. Health Aff 2007, 26:741-8.
• [36]Huizinga MM, Beech BM, Cavanaugh KL, Elasy TA, Rothman RL: Low numeracy skills are associated with higher BMI. Obesity 2008, 16:1966-1968.
• [37]Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-98.
• [38]de Jager CA, Budge MM, Clarke R: Utility of TICS-M for the assessment of cognitive function in older adults. Int J Geriatr Psychiatry 2003, 18:318-24.