Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression

BMC Psychiatry

Arne E Vaaler¹  Kjetil Sundet³  Gunnar Morken¹  Ketil J Oedegaard⁵  Ulrik F Malt⁴  Åsa Hammar⁷  Geir E Eide²  Ole A Andreassen³  Helle K Schoeyen⁶  Ute Kessler⁵ 

[1] Division of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway;Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;Institute of Clinical Medicine, University of Oslo, Oslo, Norway;Department of Psychosomatic Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway;Department of Clinical Medicine, Section of Psychiatry, University of Bergen, Bergen, Norway;Moodnet Research Group, Psychiatric Division, Stavanger University Hospital, Stavanger, Norway;Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway

关键词: Bipolar II disorder;    IQ;    MATRICS;    Cognitive functioning;    Bipolar disorder depression;   

Others  :  1124089
DOI  :  10.1186/1471-244X-13-105

 received in 2013-01-24, accepted in 2013-04-01,  发布年份 2013

【 摘 要 】

Background

The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD depression inpatients, to compare the neurocognitive functioning in patients with BD I and II, and to identify the demographic and clinical illness characteristics associated with cognitive functioning.

Methods

Acutely admitted BD I (n = 19) and BD II (n = 32) inpatients who fulfilled the DSM-IV-TR criteria for a major depressive episode were tested with the MATRICS Consensus Cognitive Battery (MCCB), the Wechsler Abbreviated Scale of Intelligence, the National Adult Reading Test, and a battery of clinical measures.

Results

Neurocognitive impairments were evident in the BD I and BD II depression inpatients within all MCCB domains. The numerical scores on all MCCB-measures were lower in the BD I group than in the BD II group, with a significant difference on one of the measures, category fluency. 68.4% of the BD I patients had clinically significant impairment (>1.5 SD below normal mean) in two or more domains compared to 37.5% of the BD II patients (p = 0.045). A significant reduction in IQ from the premorbid to the current level was seen in BD I but not BD II patients. Higher age was associated with greater neurocognitive deficits compared to age-adjusted published norms.

Conclusions

A high proportion of patients with therapy-resistant BD I or II depression exhibited global neurocognitive impairments with clinically significant severity. The cognitive impairments were more common in BD I compared to BD II patients, particularly processing speed. These findings suggest that clinicians should be aware of the severe neurocognitive dysfunction in treatment-resistant bipolar depression, particularly in BD I.

Trial registration

Trial registration number:NCT00664976

【 授权许可】

   
2013 Kessler et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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