Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling

NEUROBIOLOGY OF DISEASE

卷:42

Article

Wasseff, Sameh K.¹  Scherer, Steven S.¹ 

[1] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

关键词: Oligodendrocyte;    Astrocyte;    Gap junctions;    Connexins;   

DOI  :  10.1016/j.nbd.2011.03.003

来源: Elsevier

【 摘 要 】

In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (0:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30. We used fluorescent dyes to examine functional coupling in acute slices from the cerebra of mice lacking Cx32 and/or Cx47. In the corpus callosum, unexpectedly, oligodendrocytes appeared to be directly and exclusively coupled to other oligodendrocytes (0:0 coupling), and electron microscopy revealed gap junctions between adjacent oligodendrocytes. 0:0 coupling was more affected in mice lacking Cx32 than in mice lacking Cx47. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32, was required for 0:A coupling. (C) 2011 Elsevier Inc. All rights reserved.

【 授权许可】

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