The roles of connexins and gap junctions in the progression of cancer

Cell Communication and Signaling

Review

Yuwei Li¹  Shiwu Zhang²  Minying Zheng²  Mingming Zhou³  Shifeng Tian³  Xinyue Zhou³  Yidi Ning⁴  Xiaohui Yang⁴ 

[1] Department of Colorectal Surgery, Tianjin Union Medical Center, 300121, Tianjin, People’s Republic of China;Department of Pathology, Tianjin Union Medical Center, Nankai University, 300121, Tianjin, People’s Republic of China;Graduate School, Tianjin Medical University, 300070, Tianjin, People’s Republic of China;Nankai University School of Medicine, Nankai University, 300071, Tianjin, People’s Republic of China;

关键词: Gap junctions;    Connexins;    Post-translational modification;    Cancer;    Epithelial–mesenchymal transition;   

DOI  :  10.1186/s12964-022-01009-9

 received in 2022-10-20, accepted in 2022-12-03,  发布年份 2022

来源: Springer

【 摘 要 】

Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct information exchange between cells. Cx expression has a strong spatial specificity; however, its influence on cell behavior and information exchange between cells cannot be ignored. A variety of factors in organisms can modulate Cxs and subsequently trigger a series of responses that have important effects on cellular behavior. The expression and function of Cxs and the number and function of GJs are in dynamic change. Cxs have been characterized as tumor suppressors in the past, but recent studies have highlighted the critical roles of Cxs and GJs in cancer pathogenesis. The complex mechanism underlying Cx and GJ involvement in cancer development is a major obstacle to the evolution of therapy targeting Cxs. In this paper, we review the post-translational modifications of Cxs, the interactions of Cxs with several chaperone proteins, and the effects of Cxs and GJs on cancer.EUAGovitD21XQu5xc5u6gfVideo Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq298.gif

41116_2022_35_Article_IEq294.gif