Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

NEUROBIOLOGY OF AGING

卷:36

Article

Riese, Florian¹  Gietl, Anton¹  Zoelch, Niklaus^2,3  Henning, Anke^2,3,4  O'Gorman, Ruth⁵  Kaelin, Andrea M.¹  Leh, Sandra E.¹  Buck, Alfred⁶  Warnock, Geoffrey⁶  Edden, Richard A. E.^7,8  Luechinger, Roger^2,3  Hock, Christoph¹  Kollias, Spyros⁹  Michels, Lars⁹ 

[1] Univ Zurich, Div Psychiat Res & Psychogeriatr Med, Zurich, Switzerland

[2] Univ Zurich, Inst Biomed Engn, Zurich, Switzerland

[3] ETH, Zurich, Switzerland

[4] Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany

[5] Univ Childrens Hosp Zurich, Ctr MR Res, Zurich, Switzerland

[6] Univ Zurich Hosp, Inst Nucl Med, CH-8091 Zurich, Switzerland

[7] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[8] Kenneddy Krieger Inst, FM Kirby Ctr Funct Brain Imaging, Baltimore, MD USA

[9] Univ Zurich Hosp, Clin Neuroradiol, CH-8091 Zurich, Switzerland

关键词: Mild cognitive impairment;    Alzheimer;    Dementia;    Magnetic resonance spectroscopy;    MRS;    GABA;    Glx;    Glutamate;    Beta-amyloid;    PiB;    Posterior cingulate cortex;    APOE;   

DOI  :  10.1016/j.neurobiolaging.2014.07.030

来源: Elsevier

【 摘 要 】

The biomarker potential of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) for the in vivo characterization of preclinical stages in Alzheimer's disease has not yet been explored. We measured GABA, glutamate + glutamine (Glx), and N-acetyl-aspartate (NAA) levels by single-voxel MEGA-PRESS magnetic resonance spectroscopy in the posterior cingulate cortex of 21 elderly subjects and 15 patients with amnestic mild cognitive impairment. Participants underwent Pittsburgh Compound B positron emission tomography, apolipoprotein E (APOE) genotyping, and neuropsychological examination. GABA, Glx, and NAA levels were significantly lower in patients. NAA was lower in Pittsburgh Compound B-positive subjects and APOE epsilon 4 allele carriers. GABA, Glx, and NAA levels were positively correlated to CERAD word learning scores. Reductions in GABA, Glx, and NAA levels may serve as metabolic bio-markers for cognitive impairment in amnestic mild cognitive impairment. Because GABA and Glx do not seem to reflect amyloid beta deposition or APOE genotype, they are less likely biomarker candidates for preclinical Alzheimer's disease. (C) 2015 Elsevier Inc. All rights reserved.

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