Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:36

Article

Richiardi, Jonas^1,2,3  Monsch, Andreas U.⁴  Haas, Tanja⁵  Barkhof, Frederik⁶  Van de Ville, Dimitri^7,8  Radue, Ernst W.⁹  Kressig, Reto W.¹⁰  Haller, Sven¹¹ 

[1] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA USA

[2] Univ Geneva, Dept Neurosci, Geneva, Switzerland

[3] Univ Geneva, Dept Neurol, Geneva, Switzerland

[4] Felix Platter Hosp, Univ Ctr Med Aging Basel, Memory Clin, Basel, Switzerland

[5] Univ Basel Hosp, Dept Radiol, CH-4031 Basel, Switzerland

[6] Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[7] Univ Geneva, Fac Med, Dept Radiol & Med Informat, Geneva, Switzerland

[8] Ecole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, CH-1015 Lausanne, Switzerland

[9] Univ Basel Hosp, MIAC, CH-4031 Basel, Switzerland

[10] Felix Platter Hosp, Univ Ctr Med Aging Basel, Basel, Switzerland

[11] Hop Cantonal Univ Geneva, DISIM, Serv Neurodiagnost & Neurointervent, CH-1211 Geneva 14, Switzerland

关键词: Mild cognitive impairment;    Alzheimer;    Cognitive decline;    MRI;    Perfusion;    Carbon dioxide;    Vasoreactivity;   

DOI  :  10.1016/j.neurobiolaging.2014.07.020

来源: Elsevier

【 摘 要 】

Interindividual variation in neurovascular reserve and its relationship with cognitive performance is not well understood in imaging in neurodegeneration. We assessed the neurovascular reserve in amnestic mild cognitive impairment (aMCI) and Alzheimer's dementia (AD). Twenty-eight healthy controls (HC), 15 aMCI, and 20 AD patients underwent blood oxygen level-dependent imaging for 9 minutes, breathing alternatively air and 7% carbon dioxide mixture. The data were parcellated into 88 anatomic regions, and carbon dioxide regressors accounting for different washin and washout velocities were fitted to regional average blood oxygen leveledependent signals. Velocity of cerebrovascular reactivity (CVR) was analyzed and correlated with cognitive scores. aMCI and AD patients had significantly slower response than HC (mean time to reach 90% of peak: HC 33 seconds, aMCI and AD 59 seconds). CVR velocity correlated with Mini Mental State Examination in 35 of 88 brain regions (p = 0.019, corrected for multiple comparisons), including 10 regions of the default-mode network, an effect modulated by age. This easily applicable protocol yielded a practical assessment of CVR in cognitive decline. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free