Neural evidence for age-related differences in representational quality and strategic retrieval processes

NEUROBIOLOGY OF AGING

卷:84

Article

Trelle, Alexandra N.^1,2  Henson, Richard N.^3,4  Simons, Jon S.¹ 

[1] Univ Cambridge, Dept Psychol, Downing St, Cambridge CB2 3EB, England

[2] Stanford Univ, Dept Psychol, Stanford, CA USA

[3] MRC Cognit & Brain Sci Unit, Cambridge, England

[4] Univ Cambridge, Dept Psychiat, Cambridge, England

关键词: Aging;    Episodic memory;    Dedifferentiation;    Recollection;    Cognitive control;   

DOI  :  10.1016/j.neurobiolaging.2019.07.012

来源: Elsevier

【 摘 要 】

Mounting behavioral evidence suggests that declines in both representational quality and controlled retrieval processes contribute to episodic memory decline with age. The present study sought neural evidence for age-related change in these factors by measuring neural differentiation during encoding of paired associates and changes in regional blood oxygenation level-dependent activity and functional connectivity during retrieval conditions that placed low (intact pairs) and high (recombined pairs) demands on controlled retrieval processes. Pattern similarity analysis revealed age-related declines in the differentiation of stimulus representations at encoding, manifesting as both reduced pattern similarity between closely related events and increased pattern similarity between distinct events. During retrieval, both groups increased recruitment of areas within the core recollection network when endorsing studied pairs, including the hippocampus and angular gyms. In contrast, only younger adults increased recruitment of, and hippocampal connectivity with, lateral prefrontal regions during correct rejections of recombined pairs. These results provide evidence for age-related changes in representational quality and in the neural mechanisms supporting memory retrieval under conditions of high, but not low, control demand. (C) 2019 The Authors. Published by Elsevier Inc.

【 授权许可】

Free