Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway

NEUROBIOLOGY OF AGING

卷:41

Article

Chaker, Zayna^1,2,3,5  George, Caroline^1,2  Petrovska, Marija²  Caron, Jean-Baptiste³  Lacube, Philippe^1,2  Caille, Isabelle^2,4  Holzenberger, Martin^1,2 

[1] Hop St Antoine, INSERM, Ctr Rech, UMR938, F-75571 Paris, France

[2] Univ Paris 06, Sorbonne Univ, Paris, France

[3] Univ Paris 05, Fac Med, Paris, France

[4] INSERM, Team Dev & Plast Neural Networks, CNRS, IBPS,UMR8246,U1130, Paris, France

[5] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

关键词: Adult neurogenesis;    IGF-I;    Hypothalamus;    Tanycyte;    GHRH;    Conditional mutagenesis;   

DOI  :  10.1016/j.neurobiolaging.2016.02.008

来源: Elsevier

【 摘 要 】

Hypothalamic tanycytes are specialized glial cells lining the third ventricle. They are recently identified as adult stem and/or progenitor cells, able to self-renew and give rise to new neurons postnatally. However, the long-term neurogenic potential of tanycytes and the pathways regulating lifelong cell replacement in the adult hypothalamus are largely unexplored. Using inducible nestin-CreER(T2) for conditional mutagenesis, we performed lineage tracing of adult hypothalamic stem and/or progenitor cells (HySC) and demonstrated that new neurons continue to be born throughout adult life. This neurogenesis was targeted to numerous hypothalamic nuclei and produced different types of neurons in the dorsal periventricular regions. Some adult-born neurons integrated the median eminence and arcuate nucleus during aging and produced growth hormone releasing hormone. We showed that adult hypothalamic neurogenesis was tightly controlled by insulin-like growth factors (IGF). Knockout of IGF-1 receptor from hypothalamic stem and/or progenitor cells increased neuronal production and enhanced alpha-tanycyte self-renewal, preserving this stem cell-like population from age-related attrition. Our data indicate that adult hypothalamus retains the capacity of cell renewal, and thus, a substantial degree of structural plasticity throughout lifespan. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free