CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:91

Article

Walsh, Phoebe¹  Sudre, Carole H.^1,2,3  Fiford, Cassidy M.¹  Ryan, Natalie S.¹  Lashley, Tammaryn^4,5  Frost, Chris^1,6  Barnes, Josephine¹ 

[1] UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England

[2] Kings Coll London, Sch Biomed Engn & Imaging Sci, Dept Biomed Engn, London, England

[3] UCL, Ctr Med Image Comp, London, England

[4] UCL Queen Sq Inst Neurol, Queen Sq Brain Bank Neurol Disorders, Dept Clin & Movement Neurosci, London, England

[5] UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, London, England

[6] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, Dept Med Stat, London, England

关键词: Alzheimer's disease;    Vascular disease;    White matter hyperintensities;    Amyloid;    Tau;    Cerebrospinal fluid;   

DOI  :  10.1016/j.neurobiolaging.2020.03.008

来源: Elsevier

【 摘 要 】

This study investigated the relationship between white matter hyperintensities (WMH) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 controls, 107 individuals with a significant memory concern, 320 individuals with early mild cognitive impairment, 171 individuals with late mild cognitive impairment, and 151 individuals with AD, with 3T MRI and CSF A beta 1-42, total tau (t-tau), and phosphorylated tau (p-tau) data. Multiple linear regression models assessed the relationship between WMH and CSF A beta 1-42, t-tau, and p-tau. Directionally, a higher WMH burden was associated with lower CSF A beta 1-42 within each diagnostic group, with no evidence for a difference in the slope of the association across diagnostic groups (p = 0.4). Pooling all participants, this association was statistically significant after adjustment for t-tau, p-tau, age, diagnostic group, and APOE-epsilon 4 status (p < 0.001). Age was the strongest predictor of WMH (partial R-2 similar to 16%) compared with CSF A beta 1-42 (partial R-2 similar to 5%). There was no evidence for an association with WMH and either t-tau or p-tau. These data are supportive of a link between amyloid burden and presumed vascular pathology. (C) 2020 Elsevier Inc. All rights reserved.

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