Cortical thinning is associated with brain pulsatility in older adults: An MRI and NIRS study

NEUROBIOLOGY OF AGING

卷:106

Article

Mohammadi, Hanieh^1,2,6,7  Peng, Ke^3,4,5  Kassab, Ali⁵  Nigam, Anil⁶  Bherer, Louis^2,6  Lesage, Frederic^1,6  Joanette, Yves^2,7 

[1] Polytech Montreal, Biomed Engn Inst, Lab Opt & Mol Imaging, 2900 Edouard Montpetit Blvd, Montreal, PQ H3T 1J4, Canada

[2] Univ Inst Geriatr Montreal, Res Ctr, Montreal, PQ, Canada

[3] Boston Childrens Hosp, Ctr Pain & Brain, Boston, MA USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Univ Montreal, Hlth Ctr, Res Ctr, Montreal, PQ, Canada

[6] EPIC Ctr Montreal Heart Inst, Res Ctr, Montreal, PQ, Canada

[7] Univ Montreal, Fac Med, Montreal, PQ, Canada

关键词: Near-infrared spectroscopy;    Cerebral pulsatility;    Cortical thinning;    Aging;    Cognitive decline;   

DOI  :  10.1016/j.neurobiolaging.2021.05.002

来源: Elsevier

【 摘 要 】

Aging is accompanied by global brain atrophy occurring unequally across the brain. Cortical thinning is seen with aging with a larger loss in the frontal and temporal subregions. We explored the link between regional cortical thickness and regional cerebral pulsatility. Sixty healthy individuals were divided into two age groups, young (aged 19-31) and older (aged 65-75) adults. Each participant underwent a near infrared spectroscopy (NIRS) scan to index regional brain pulsatility from cerebral pulse-transit-time-to the peak-of-the-pulse (PTTp), an anatomical magnetic resonance imaging (MRI) and a phase-contrast MRI (PC-MRI) scan to measure arterial and cerebrospinal fluid (CSF) pulsatility. In older adults, the greatest association between cerebral pulsatility and cortical thickness was found in superior and middle temporal and superior, middle and inferior frontal areas, which are the regions perfused first by the internal carotid arteries. This association dropped in the postcentral and superior parietal regions. These findings suggest higher brain pulsatility as a potential risk factor contributing to cortical thinning for some brain regions more than others. (c) 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

【 授权许可】

Free