The association of sleep-disordered breathing with high cerebral pulsatility might not be related to diffuse small vessel disease. A pilot study

BMC Research Notes

Juan A. Nader⁴  Mauricio Zambrano²  María de la Luz Andrade⁴  Oscar H. Del Brutto¹  Pablo R. Castillo³ 

[1] School of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador;Community Center, The Atahualpa Project, Atahualpa, Ecuador;Division of Sleep Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville 32224, FL, USA;Department of Neurology, Hospital Médica Sur, Mexico City, Mexico

关键词: White matter hyperintensities;    Transcranial Doppler;    Sleep-disordered breathing;    Pulsatility index;    Cerebral small vessel disease;    Cerebral pulsatility;   

Others  :  1229933
DOI  :  10.1186/s13104-015-1481-5

 received in 2015-02-25, accepted in 2015-09-21,  发布年份 2015

【 摘 要 】

Background

In a population-based sampling study conducted in community-dwelling older adults living in rural Ecuador, we aimed to assess the relation among sleep-disordered breathing, cerebral pulsatility index, and diffuse small vessel disease.

Methods

Of 25 participants, 9 (36 %) had moderate-to-severe sleep-disordered breathing, characterized by an apnea/hypopnea index ≥15 per hour, and 10 (40 %) had moderate-to-severe white matter hyperintensities, graded according to the modified Fazekas scale. Mean (SD) pulsatility index in the middle cerebral artery was 1.18 (0.19) and positively correlated with the apnea/hypopnea index (R = .445, P = .03, [Pearson’s correlation coefficient]). The middle cerebral artery pulsatility index was increased in persons with moderate-to-severe sleep-disordered breathing compared with persons who had none-to-mild sleep-disordered breathing (mean [SD] 1.11 [0.12] vs. 1.3 [0.23], P = .01). No significant differences were found in the prevalence of moderate-to-severe white matter hyperintensities across groups of sleep-disordered breathing (P = .40) or in the mean apnea/hypopnea index across groups of persons with none-to-mild or moderate-to-severe white matter hyperintensities (P = .16).

Conclusions

This pilot study shows that moderate-to-severe sleep-disordered breathing correlates with cerebral pulsatility, but such association might be independent of diffuse small vessel disease.

【 授权许可】

   
2015 Castillo et al.

【 图 表 】

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