Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

NEUROBIOLOGY OF AGING

卷:65

Article

Babiloni, Claudio^1,2  Del Percio, Claudio³  Lizio, Roberta^1,2  Noce, Giuseppe³  Lopez, Susanna¹  Soricelli, Andrea^3,4  Ferri, Raffaele⁵  Nobili, Flavio^6,7  Arnaldi, Dario^6,7  Fama, Francesco^6,7  Aarsland, Dag⁸  Orzi, Francesco⁹  Buttinelli, Carla⁹  Giubilei, Franco⁹  Onofrj, Marco^10,11  Stocchi, Fabrizio²  Stirpe, Paola²  Fuhr, Peter¹²  Gschwandtner, Ute¹²  Ransmayr, Gerhard^13,14  Garn, Heinrich¹⁵  Fraioli, Lucia¹⁶  Pievani, Michela¹⁷  Frisoni, Giovanni B.^17,18,19,20  D'Antonio, Fabrizia²¹  De Lena, Carlo²¹  Guntekin, Bahar²²  Hanoglu, Lutfu²³  Bazar, Erol^24,25  Yener, Gorsev^24,25  Emek-Savas, Derya Durusu^26,27  Triggiani, Antonio Ivano²⁸  Franciotti, Raffaella^10,11  Taylor, John Paul²⁹  Vacca, Laura^2,30  De Pandis, Maria Francesca¹⁶  Bonanni, Laura^10,11 

[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

[2] IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy

[3] IRCCS, SDN, Dept Integrated Imaging, Naples, Italy

[4] Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy

[5] IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy

[6] Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy

[7] IRCCS, AOU S Martino IST, Genoa, Italy

[8] Kings Coll Univ, Dept Old Age Psychiat, London, England

[9] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[10] Univ G Annunzio Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[11] Univ G Annunzio Chieti Pescara, CESI, Chieti, Italy

[12] Univ Spita Basel, Abt Neurophysiol, Basel, Switzerland

[13] Johannes Kepler Univ Linz, Gen Hosp City Linz, Dept Neurol & Psychiat, Linz, Austria

[14] Johannes Kepler Univ Linz, Gen Hosp City Linz, Fac Med, Linz, Austria

[15] AIT Austrian Inst Technol GmbH, Vienna, Austria

[16] Hosp San Raffaele Cassino, Cassino, Italy

[17] IRCCS, Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[18] Univ Hosp, Lab Neuroimaging Aging, Memory Clin, Geneva, Switzerland

[19] Univ Hosp, Lab Neuroimaging Aging, LANVIE, Geneva, Switzerland

[20] Univ Geneva, Geneva, Switzerland

[21] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[22] Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey

[23] Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey

[24] Dokuz Eyliil Univ, IBG, Dept Neurol, Izmir, Turkey

[25] Dokuz Eyliil Univ, IBG, Dept Neurosci, Izmir, Turkey

[26] Dokuz Eyliil Univ, Dept Psychol, Izmir, Turkey

[27] Dokuz Eyliil Univ, Dept Neurosci, Izmir, Turkey

[28] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[29] Newcastle Univ, Inst Neurosci, Newcastle, NSW, Australia

[30] Casa Cura Privata Policlin CCPP Milano SpA, Milan, Italy

关键词: Functional brain connectivity;    Resting-state EEG rhythms;    Neurodegenerative diseases;    Dementia;    Alzheimer's disease;    Parkinson's disease;    Dementia with Lewy bodies;   

DOI  :  10.1016/j.neurobiolaging.2017.12.023

来源: Elsevier

【 摘 要 】

Previous evidence showed abnormal posterior sources of resting-state delta (< 4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a disconnection cortical syndrome, in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Hold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

Free